ArticleMolecular biology of the cell2007
Caenorhabditis elegans intersectin: a synaptic protein regulating neurotransmission.
Article in Molecular biology of the cell, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 32 citations in OpenAlex.
- Integrating MACSPI and SILAC for Neuron Type-specific Proteomics in Caenorhabditis elegans.Molecular & cellular proteomics : MCP · 2026Article
- Loss of periactive-zone scaffold proteins does not enhance neurotransmission defects inmicroPublication biology · 2026Article
- Differential roles for CLA-1L and UNC-10 in endosomal maturation and peptide release atFrontiers in molecular biosciences · 2025Article
- Endosome Dysregulation in Down Syndrome: A Potential Contributor to Alzheimer Disease Pathology.Annals of neurology · 2021Review
- Intersectin scaffold proteins and their role in cell signaling and endocytosis.Biochimica et biophysica acta. Molecular cell research · 2017Review
- CDC-42 Orients Cell Migration during Epithelial Intercalation in the Caenorhabditis elegans Epidermis.PLoS genetics · 2016Article
- Intersectin-1s: an important regulator of cellular and molecular pathways in lung injury.Pulmonary circulation · 2013Article
- Emerging roles for intersectin (ITSN) in regulating signaling and disease pathways.International journal of molecular sciences · 2013Review
- Vertebrate intersectin1 is repurposed to facilitate cortical midline connectivity and higher order cognition.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Intersectin: The Crossroad between Vesicle Exocytosis and Endocytosis.Frontiers in endocrinology · 2013Article
- A snapshot of the physical and functional wiring of the Eps15 homology domain network in the nematode.PloS one · 2013Article
- Synaptic vesicle endocytosis.Cold Spring Harbor perspectives in biology · 2012Review
- Impaired caveolae function and upregulation of alternative endocytic pathways induced by experimental modulation of intersectin-1s expression in mouse lung endothelium.Biochemistry research international · 2012Article
- Intersectin (ITSN) family of scaffolds function as molecular hubs in protein interaction networks.PloS one · 2012Article
- The Caenorhabditis elegans Eph receptor activates NCK and N-WASP, and inhibits Ena/VASP to regulate growth cone dynamics during axon guidance.PLoS genetics · 2012Article
- Control of synapse development and plasticity by Rho GTPase regulatory proteins.Progress in neurobiology · 2011Review
- Intersecting pathways in cell biology.Science signaling · 2010Review
- Secretory Carrier Membrane Protein 2 Regulates Cell-surface Targeting of Brain-enriched Na+/H+ Exchanger NHE5.The Journal of biological chemistry · 2009Article
- Intersectin regulates dendritic spine development and somatodendritic endocytosis but not synaptic vesicle recycling in hippocampal neurons.The Journal of biological chemistry · 2009Article
- Profiling synaptic proteins identifies regulators of insulin secretion and lifespan.PLoS genetics · 2008Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intersectin is a multifunctional protein that interacts with components of the endocytic and exocytic pathways, and it is also involved in the control of actin dynamics. Drosophila intersectin is required for viability, synaptic development, and synaptic vesicle recycling. Here, we report the characterization of intersectin function in Caenorhabditis elegans. Nematode intersectin (ITSN-1) is expressed in the nervous system, and it is enriched in presynaptic regions. The C. elegans intersectin gene (itsn-1) is nonessential for viability. In addition, itsn-1-null worms do not display any evident phenotype, under physiological conditions. However, they display aldicarb-hypersensitivity, compatible with a negative regulatory role of ITSN-1 on neurotransmission. ITSN-1 physically interacts with dynamin and EHS-1, two proteins involved in synaptic vesicle recycling. We have previously shown that EHS-1 is a positive modulator of synaptic vesicle recycling in the nematode, likely through modulation of dynamin or dynamin-controlled pathways. Here, we show that ITSN-1 and EHS-1 have opposite effects on aldicarb sensitivity, and on dynamin-dependent phenotypes. Thus, the sum of our results identifies dynamin, or a dynamin-controlled pathway, as a potential target for the negative regulatory role of ITSN-1.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.