ArticleJournal of virology2007
Mouse cytomegalovirus microRNAs dominate the cellular small RNA profile during lytic infection and show features of posttranscriptional regulation.
Article in Journal of virology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
61 citing papers in PubMed, 97 citations in OpenAlex.
- Review
- Inter-regulatory role of microRNAs in interaction between viruses and stem cells.World journal of stem cells · 2021Review
- The m15 Locus of Murine Cytomegalovirus Modulates Natural Killer Cell Responses to Promote Dissemination to the Salivary Glands and Viral Shedding.Pathogens (Basel, Switzerland) · 2021Article
- Human Cytomegalovirus Host Interactions: EGFR and Host Cell Signaling Is a Point of Convergence Between Viral Infection and Functional Changes in Infected Cells.Frontiers in microbiology · 2021Review
- Techniques for Characterizing Cytomegalovirus-Encoded miRNAs.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Screening and validation of differentially expressed microRNAs and target genes in hypertensive mice induced by cytomegalovirus infection.Bioscience reports · 2020Article
- A Nuclease Protection ELISA Assay for Colorimetric and Electrochemical Detection of Nucleic Acids.Analytical methods : advancing methods and applications · 2019Article
- Please stand by: how oncolytic viruses impact bystander cells.Future virology · 2018Review
- On the Importance of Host MicroRNAs During Viral Infection.Frontiers in genetics · 2018Review
- Manipulation of Viral MicroRNAs as a Potential Antiviral Strategy for the Treatment of Cytomegalovirus Infection.Viruses · 2017Article
- Uridylation and adenylation of RNAs.Science China. Life sciences · 2015Review
- Cytomegalovirus microRNAs.Current opinion in virology · 2014Review
- Article
- Novel HIV-1 miRNAs stimulate TNFα release in human macrophages via TLR8 signaling pathway.PloS one · 2014Article
- Human cytomegalovirus-encoded miR-US25-1 aggravates the oxidised low density lipoprotein-induced apoptosis of endothelial cells.BioMed research international · 2014Article
- Functional genomics approaches to understand cytomegalovirus replication, latency and pathogenesis.Current opinion in virology · 2013Review
- RNAi suppressor P19 can be broadly exploited for enhanced adenovirus replication and microRNA knockdown experiments.Scientific reports · 2013Article
- Rhesus cytomegalovirus encodes seventeen microRNAs that are differentially expressed in vitro and in vivo.Virology · 2012Article
- Small RNA deep sequencing identifies microRNAs and other small noncoding RNAs from human herpesvirus 6B.Journal of virology · 2012Article
- Degradation of cellular mir-27 by a novel, highly abundant viral transcript is important for efficient virus replication in vivo.PLoS pathogens · 2012Article
1 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
MicroRNAs (miRNAs) are small, noncoding RNA molecules that regulate gene expression at the posttranscriptional level. Originally identified in a variety of organisms ranging from plants to mammals, miRNAs have recently been identified in several viruses. Viral miRNAs may play a role in modulating both viral and host gene expression. Here, we report on the identification and characterization of 18 viral miRNAs from mouse fibroblasts lytically infected with the murine cytomegalovirus (MCMV). The MCMV miRNAs are expressed at early times of infection and are scattered in small clusters throughout the genome with up to four distinct miRNAs processed from a single transcript. No significant homologies to human CMV-encoded miRNAs were found. Remarkably, as soon as 24 h after infection, MCMV miRNAs constituted about 35% of the total miRNA pool, and at 72 h postinfection, this proportion was increased to more than 60%. However, despite the abundance of viral miRNAs during the early phase of infection, the expression of some MCMV miRNAs appeared to be regulated. Hence, for three miRNAs we observed polyuridylation of their 3' end, coupled to subsequent degradation. Individual knockout mutants of two of the most abundant MCMV miRNAs, miR-m01-4 and miR-M44-1, or a double knockout mutant of miR-m21-1 and miR-M23-2, incurred no or only a very mild growth deficit in murine embryonic fibroblasts in vitro.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.