ArticleTuberculosis (Edinburgh, Scotland)2008
Increased expression of host iron-binding proteins precedes iron accumulation and calcification of primary lung lesions in experimental tuberculosis in the guinea pig.
Article in Tuberculosis (Edinburgh, Scotland), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 44 citations in OpenAlex.
- Chest CT findings in drug-resistant pulmonary tuberculosis: a comparative analysis of elderly and non-elderly patients.BMC infectious diseases · 2025Article
- Review
- A Multimodal Desorption Electrospray Ionisation Workflow Enabling Visualisation of Lipids and Biologically Relevant Elements in a Single Tissue Section.Metabolites · 2023Article
- Characterisation and development of histopathological lesions in a guinea pig model ofFrontiers in veterinary science · 2023Article
- Accumulation of EBI3 induced by virulent Mycobacterium tuberculosis inhibits apoptosis in murine macrophages.Pathogens and disease · 2019Article
- Mycobacterial extracellular vesicles and host pathogen interactions.Pathogens and disease · 2018Review
- Adipocyte Model of Mycobacterium tuberculosis Infection Reveals Differential Availability of Iron to Bacilli in the Lipid-Rich Caseous Environment.Infection and immunity · 2018Article
- Functions and importance of mycobacterial extracellular vesicles.Applied microbiology and biotechnology · 2016Review
- Imaging Features of Pulmonary CT in Type 2 Diabetic Patients with Multidrug-Resistant Tuberculosis.PloS one · 2016Article
- Effects of Environmental Pollutants on Cellular Iron Homeostasis and Ultimate Links to Human Disease.Environmental health insights · 2016Article
- Animal models of tuberculosis: Guinea pigs.Cold Spring Harbor perspectives in medicine · 2014Review
- Mycobacterium microti tuberculosis in its maintenance host, the field vole (Microtus agrestis): characterization of the disease and possible routes of transmission.Veterinary pathology · 2014Article
- Therapeutic vaccination against relevant high virulence clinical isolates of Mycobacterium tuberculosis.Tuberculosis (Edinburgh, Scotland) · 2014Article
- Tuberculosis vaccine with high predicted population coverage and compatibility with modern diagnostics.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- A new unifying theory of the pathogenesis of tuberculosis.Tuberculosis (Edinburgh, Scotland) · 2014Article
- Mycobacterium tuberculosis infection in young children: analyzing the performance of the diagnostic tests.PloS one · 2014Article
- Mycobacterium avium infection induces H-ferritin expression in mouse primary macrophages by activating Toll-like receptor 2.PloS one · 2013Article
- Uptake and accumulation of oxidized low-density lipoprotein during Mycobacterium tuberculosis infection in guinea pigs.PloS one · 2012Article
- Article
- Development of new vaccines and drugs for TB: limitations and potential strategic errors.Future microbiology · 2011Review
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Authors and funding
11 authors at 2 institutions in 1 country.
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Abstract
The growth and virulence of Mycobacterium tuberculosis depends on its ability to scavenge host iron, an essential and limited micronutrient in vivo. In this study, we show that ferric iron accumulates both intra- and extra-cellularly in the primary lung lesions of guinea pigs aerosol-infected with the H37Rv strain of M. tuberculosis. Iron accumulated within macrophages at the periphery of the primary granulomatous lesions while extra-cellular ferric iron was concentrated in areas of lesion necrosis. Accumulation of iron within primary lesions was preceded by an increase in expression of heavy chain (H) ferritin, lactoferrin and receptors for transferrin, primarily by macrophages and granulocytes. The increased expression of intra-cellular H ferritin and extra-cellular lactoferrin, more so than transferrin receptor, paralleled the development of necrosis within primary lesions. The deposition of extra-cellular ferric iron within necrotic foci coincided with the accumulation of calcium and phosphorus and other cations in the form of dystrophic calcification. Primary lung lesions from guinea pigs vaccinated with Mycobactrium bovis BCG prior to experimental infection, had reduced iron accumulation as well as H ferritin, lactoferrin and transferrin receptor expression. The amelioration of primary lesion necrosis and dystrophic calcification by BCG vaccination was coincident with the lack of extra-cellular ferric iron and lactoferrin accumulation. These data demonstrate that BCG vaccination ameliorates primary lesion necrosis, dystrophic mineralization and iron accumulation, in part by down-regulating the expression of macrophage H ferritin, lactoferrin and transferrin receptors, in vivo.
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