ArticlePLoS biology2007
A novel Snf2 protein maintains trans-generational regulatory states established by paramutation in maize.
Article in PLoS biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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44 citing papers in PubMed, 95 citations in OpenAlex.
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- Upstream regulator of genomic imprinting in rice endosperm is a small RNA-associated chromatin remodeler.Nature communications · 2024Article
- Paramutation at the maize pl1 locus is associated with RdDM activity at distal tandem repeats.PLoS genetics · 2024Article
- CHROMOMETHYLTRANSFERASE3/KRYPTONITE maintains theProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Reinforcement of CHH methylation through RNA-directed DNA methylation ensures sexual reproduction in rice.Plant physiology · 2022Article
- Article
- Comprehensive Mechanism of Gene Silencing and Its Role in Plant Growth and Development.Frontiers in plant science · 2021Review
- Locus-specific paramutation in Zea mays is maintained by a PICKLE-like chromodomain helicase DNA-binding 3 protein controlling development and male gametophyte function.PLoS genetics · 2020Article
- Loss of RNA-Directed DNA Methylation in Maize Chromomethylase and DDM1-Type Nucleosome Remodeler Mutants.The Plant cell · 2018Article
- Locus-specific control of the de novo DNA methylation pathway in Arabidopsis by the CLASSY family.Nature genetics · 2018Article
- Subtle Perturbations of the Maize Methylome Reveal Genes and Transposons Silenced by Chromomethylase or RNA-Directed DNA Methylation Pathways.G3 (Bethesda, Md.) · 2018Article
- Altered nucleosome positions in maize haplotypes and mutants of a subset of SWI/SNF-like proteins.Plant direct · 2017Article
- Article
- Paramutation and related phenomena in diverse species.Nature reviews. Genetics · 2017Review
- Trans-Homolog Interactions Facilitating Paramutation in Maize.Plant physiology · 2015Review
- Involvement of Multiple Gene-Silencing Pathways in a Paramutation-like Phenomenon in Arabidopsis.Cell reports · 2015Article
- Article
- Diverse gene-silencing mechanisms with distinct requirements for RNA polymerase subunits in Zea mays.Genetics · 2014Article
- Chromatin structure and gene expression changes associated with loss of MOP1 activity in Zea mays.Epigenetics · 2014Article
- The maize methylome influences mRNA splice sites and reveals widespread paramutation-like switches guided by small RNA.Genome research · 2013Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Paramutations represent heritable epigenetic alterations that cause departures from Mendelian inheritance. While the mechanism responsible is largely unknown, recent results in both mouse and maize suggest paramutations are correlated with RNA molecules capable of affecting changes in gene expression patterns. In maize, multiple required to maintain repression (rmr) loci stabilize these paramutant states. Here we show rmr1 encodes a novel Snf2 protein that affects both small RNA accumulation and cytosine methylation of a proximal transposon fragment at the Pl1-Rhoades allele. However, these cytosine methylation differences do not define the various epigenetic states associated with paramutations. Pedigree analyses also show RMR1 does not mediate the allelic interactions that typically establish paramutations. Strikingly, our mutant analyses show that Pl1-Rhoades RNA transcript levels are altered independently of transcription rates, implicating a post-transcriptional level of RMR1 action. These results suggest the RNA component of maize paramutation maintains small heterochromatic-like domains that can affect, via the activity of a Snf2 protein, the stability of nascent transcripts from adjacent genes by way of a cotranscriptional repression process. These findings highlight a mechanism by which alleles of endogenous loci can acquire novel expression patterns that are meiotically transmissible.
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