ArticlePLoS genetics2007
Telomeric trans-silencing: an epigenetic repression combining RNA silencing and heterochromatin formation.
Article in PLoS genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
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Who cites it
63 citing papers in PubMed, 112 citations in OpenAlex.
- Retrovirus insertions in host transcripts trigger de novo piRNA immunity.The EMBO journal · 2026Article
- Adaptive P-element Insertions in a Long Non-Coding RNA are Potential Emerging piRNA Clusters.Genome biology and evolution · 2026Article
- Rapid evolution and comparative analysis of piRNA clusters inbioRxiv : the preprint server for biology · 2026Article
- Transforming Cancer Diagnostics: The Emergence of Liquid Biopsy and Epigenetic Markers.MedComm · 2025Review
- The impact of insertion bias into piRNA clusters on the invasion of transposable elements.BMC biology · 2025Article
- Evolution of piRNA-guided defense against transposable elements.Trends in genetics : TIG · 2025Review
- Article
- The composition of piRNA clusters in Drosophila melanogaster deviates from expectations under the trap model.BMC biology · 2023Article
- Modeling early germline immunization after horizontal transfer of transposable elements reveals internal piRNA cluster heterogeneity.BMC biology · 2023Article
- The histone demethylase Kdm3 prevents auto-immune piRNAs production inScience advances · 2023Article
- Satellitome Analysis onGenes · 2022Article
- The Transposition Rate Has Little Influence on the Plateauing Level of the P-element.Molecular biology and evolution · 2022Article
- Review
- The Transposable Elements of the Drosophila serrata Reference Panel.Genome biology and evolution · 2021Article
- Roles of piRNAs in transposon and pseudogene regulation of germline mRNAs and lncRNAs.Genome biology · 2021Review
- Mechanism and regulation of P element transposition.Open biology · 2020Review
- Paternally Inherited P-Element Copy Number Affects the Magnitude of Hybrid Dysgenesis in Drosophila simulans and D. melanogaster.Genome biology and evolution · 2020Article
- piRNA Clusters Need a Minimum Size to Control Transposable Element Invasions.Genome biology and evolution · 2020Article
- Article
- Environmentally-Induced Transgenerational Epigenetic Inheritance: Implication of PIWI Interacting RNAs.Cells · 2019Review
3 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The study of P-element repression in Drosophila melanogaster led to the discovery of the telomeric Trans-Silencing Effect (TSE), a repression mechanism by which a transposon or a transgene inserted in subtelomeric heterochromatin (Telomeric Associated Sequence or TAS) has the capacity to repress in trans in the female germline, a homologous transposon, or transgene located in euchromatin. TSE shows variegation among egg chambers in ovaries when silencing is incomplete. Here, we report that TSE displays an epigenetic transmission through meiosis, which involves an extrachromosomal maternally transmitted factor. We show that this silencing is highly sensitive to mutations affecting both heterochromatin formation (Su(var)205 encoding Heterochromatin Protein 1 and Su(var)3-7) and the repeat-associated small interfering RNA (or rasiRNA) silencing pathway (aubergine, homeless, armitage, and piwi). In contrast, TSE is not sensitive to mutations affecting r2d2, which is involved in the small interfering RNA (or siRNA) silencing pathway, nor is it sensitive to a mutation in loquacious, which is involved in the micro RNA (or miRNA) silencing pathway. These results, taken together with the recent discovery of TAS homologous small RNAs associated to PIWI proteins, support the proposition that TSE involves a repeat-associated small interfering RNA pathway linked to heterochromatin formation, which was co-opted by the P element to establish repression of its own transposition after its recent invasion of the D. melanogaster genome. Therefore, the study of TSE provides insight into the genetic properties of a germline-specific small RNA silencing pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.