ArticleJournal of muscle research and cell motility2007
T-tubule formation in cardiacmyocytes: two possible mechanisms?
Article in Journal of muscle research and cell motility, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 58 citations in OpenAlex.
- Early Stage Morphogenesis of Transverse Tubules in Rat Cardiomyocytes: The Role of pBIN1.Circulation research · 2025Article
- From function to structure: how myofibrillogenesis influences the transverse-axial tubular system development and its peculiarities.Frontiers in physiology · 2025Review
- The Dysferlinopathies Conundrum: Clinical Spectra, Disease Mechanism and Genetic Approaches for Treatments.Biomolecules · 2024Review
- Endoplasmic Reticulum-Plasma Membrane Junctions as Sites of Depolarization-Induced CaAnnual review of physiology · 2023Review
- Evolution of the cardiac dyad.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Review
- Mechanisms and physiological implications of cooperative gating of clustered ion channels.Physiological reviews · 2022Review
- SIRT1 regulates cardiomyocyte alignment during maturation.Journal of cell science · 2022Article
- Cardiac effects and clinical applications of MG53.Cell & bioscience · 2021Review
- The Mechanics and Thermodynamics of Tubule Formation in Biological Membranes.The Journal of membrane biology · 2021Review
- Editorial: Cardiomyocyte Maturation: Novel Insights for Regenerative Medicine.Frontiers in cell and developmental biology · 2021Article
- The architecture and function of cardiac dyads.Biophysical reviews · 2020Review
- How CaThe Journal of general physiology · 2019Article
- BIN1 Induces the Formation of T-Tubules and Adult-Like CaStem cells (Dayton, Ohio) · 2019Article
- MG53 is dispensable for T-tubule maturation but critical for maintaining T-tubule integrity following cardiac stress.Journal of molecular and cellular cardiology · 2017Article
- Caveolae in Rabbit Ventricular Myocytes: Distribution and Dynamic Diminution after Cell Isolation.Biophysical journal · 2017Article
- Cardiac T-Tubule Microanatomy and Function.Physiological reviews · 2017Review
- Early transverse tubule development begins in utero in the sheep heart.Journal of muscle research and cell motility · 2016Article
- Simultaneous imaging of local calcium and single sarcomere length in rat neonatal cardiomyocytes using yellow Cameleon-Nano140.The Journal of general physiology · 2016Article
- Comparative Gene Expression Analysis of Mouse and Human Cardiac Maturation.Genomics, proteomics & bioinformatics · 2016Article
- Transcriptional Landscape of Cardiomyocyte Maturation.Cell reports · 2015Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
We have followed the differentiation of transverse (T) tubules and of the associations between sarcoplasmic reticulum (SR) and either the plasmalemma (peripheral couplings) or the T tubules (dyads) in postnatal rat ventricular myocytes using electron microscopy. Dyads and peripheral couplings are collectively called Ca(2+) Release Units (CRUs) because they are the sites at which Ca(2+) is released from the SR. Profiles of T tubules, caveolae and dyads are mostly at the cell edge in early postnatal days and are found with increased frequency in the cell interior during the first two postnatal weeks. Using ferritin to trace continuity of T tubules lumen with the extracellular space, we find that some of T tubules (between approximately 6 and 25%), either singly or within dyads, lack ferritin in their lumen. The percentage of tubules that do not contain ferritin decreases slightly during postnatal differentiation and is not very different at the cells' edges and interior. We propose that T tubules form as invaginations of the plasmalemma that penetrate inward driven by accrual of membrane lipids and specific proteins. This occurs by a dual mechanism: either by the independent flow of SR and T tubule proteins into the two separate membranes or by the fusion of preformed vesicle tandems into the dyads. Most of the CRUs (approximately 86%) are constituted by peripheral couplings and ferritin containing dyads, thus constituting CRUs in which Ca(2+ )release from the SR is initiated by a membrane depolarization. In the remaining CRUs, activation of Ca(2+) release must be dependent on some other mechanisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.