Trial reportPsychopharmacology2008
The role of 5-HTTLPR in choosing the lesser of two evils, the better of two goods: examining the impact of 5-HTTLPR genotype and tryptophan depletion in object choice.
Trial report in Psychopharmacology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The Genetics of Risk Aversion: A Systematic Review.International journal of environmental research and public health · 2022Pooled it
- The genetic underpinnings of callous-unemotional traits: A systematic research review.Neuroscience and biobehavioral reviews · 2019Pooled it
- The influence of serotonin on fear learning.PloS one · 2012Trial
- Risk-seeking for losses is associated with 5-HTTLPR, but not with transient changes in 5-HT levels.Psychopharmacology · 2018Article
- Serotonin Transporter Genetic Variation is Differentially Associated with Reflexive- and Reflective-Optimal Learning.Cerebral cortex (New York, N.Y. : 1991) · 2017Article
- Reduced sensitivity to both positive and negative reinforcement in mice over-expressing the 5-hydroxytryptamine transporter.The European journal of neuroscience · 2014Article
- The neurobiology of psychopathic traits in youths.Nature reviews. Neuroscience · 2013Review
- Association between the serotonin transporter triallelic genotype and eating problems is moderated by the experience of childhood trauma in women.The International journal of eating disorders · 2012Article
- Epigenetics in Developmental Disorder: ADHD and Endophenotypes.Journal of genetic syndromes & gene therapy · 2011Article
- Serotonin Transporter (5-HTTLPR) Genotype and Childhood Trauma are Associated with Individual Differences in Decision Making.Frontiers in genetics · 2011Article
- The roles of dopamine and serotonin in decision making: evidence from pharmacological experiments in humans.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2011Review
- Risk-taking behavior in a gambling task associated with variations in the tryptophan hydroxylase 2 gene: relevance to psychiatric disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2010Article
- Gender moderates the association between 5-HTTLPR and decision-making under ambiguity but not under risk.Neuropharmacology · 2010Article
- Genetic contributions of the serotonin transporter to social learning of fear and economic decision making.Social cognitive and affective neuroscience · 2009Article
- A genetically mediated bias in decision making driven by failure of amygdala control.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
rationaleThe serotonin (5-HT) system is considered important for decision-making. However, its role in reward- and punishment-based processing has not yet been clearly determined.
objectivesThe present study examines the effect of 5-HTTLPR genotype and tryptophan depletion on reward- and punishment-related processing, using a task that considers decision-making in situations of subtlety of choice. Thus, it considers that response choice often occurs in situations where both options are desirable (e.g., choosing between mousse au chocolat or crème caramel cheesecake from a menu) or undesirable. It also considers that response choice is easier when the reinforcements associated with the options are far apart, rather than close, in value. MATERIALS AND
methodsHealthy volunteers underwent acute tryptophan depletion (ATD) or control procedures and genotyping of the 5-HTTLPR for long and short allele variants. We then examined the effects and interactions of ATD and the serotonin promoter polymorphism genotype on two aspects of decision-making: (a) decision form, choosing between two objects to gain the greater reward or lesser punishment and (b) between-object reinforcement distance, the difference in reinforcements associated with two options.
resultsATD and LL homozygosity had comparable interactions with decision form and between-object reinforcement distance. Specifically, both modulated the effect of between-object reinforcement distance when deciding between objects both associated with punishment. Moreover, ATD and genotype interacted with ATD disproportionately affecting the performance of the LL homozygous group.
conclusionsThese results suggest that serotonin is particularly associated with punishment, rather than reward-related processing, and that individual sensitivity to punishment-related information and tryptophan depletion varies with genotype.
Indexed as
Identifiers
17940752What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.