ReviewThe Yale journal of biology and medicine2006
Mechanisms of oncogenic cooperation in cancer initiation and metastasis.
Review in The Yale journal of biology and medicine, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.
- The Effects of Hysterectomy on Urinary and Sexual Functions of Women with Cervical Cancer: A Systematic Review.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2022Pooled it
- Review
- Exploring the Therapeutic Potential of Bovine Colostrum for Cancer Therapies.International journal of molecular sciences · 2025Review
- An Insight into Cancer Cells and Disease Progression Through the Lens of Mathematical Modeling.Current issues in molecular biology · 2025Review
- A Review of Telomere Attrition in Cancer and Aging: Current Molecular Insights and Future Therapeutic Approaches.Cancers · 2025Review
- The Supression of Migration and Metastasis via Inhibition of Vascular Endothelial Growth Factor in Pancreatic Adenocarcinoma Cells Applied Danusertib.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2024Article
- Metformin reduces basal subpopulation and attenuates mammary epithelial cell stemness in FVB/N mice.Frontiers in cell and developmental biology · 2024Article
- Oncogenic context shapes the fitness landscape of tumor suppression.Nature communications · 2023Article
- CD33-targeting extracellular vesicles deliver antisense oligonucleotides against FLT3-ITD and miR-125b for specific treatment of acute myeloid leukaemia.Cell proliferation · 2022Article
- Article
- Unraveling the physiological roles of retinoic acid receptor-related orphan receptor α.Experimental & molecular medicine · 2021Review
- Functional genomics of AP-2α and AP-2γ in cancers: in silico study.BMC medical genomics · 2020Article
- Diuron exposure and Akt overexpression promote glioma formation through DNA hypomethylation.Clinical epigenetics · 2019Article
- HCMDB: the human cancer metastasis database.Nucleic acids research · 2018Article
- Effects of four single nucleotide polymorphisms ofOncoTargets and therapy · 2018Article
- Phospholipase D and Its Essential Role in Cancer.Molecules and cells · 2017Review
- Naringenin suppresses K562 human leukemia cell proliferation and ameliorates Adriamycin-induced oxidative damage in polymorphonuclear leukocytes.Experimental and therapeutic medicine · 2015Article
- Autofluorescence spectroscopy and imaging: a tool for biomedical research and diagnosis.European journal of histochemistry : EJH · 2014Review
- Chemopreventive and chemotherapeutic effects of genistein, a soy isoflavone, upon cancer development and progression in preclinical animal models.Laboratory animal research · 2014Review
- Intra-tumoral Metastatic Double Primary Carcinoma: Synchronous Metastatic Tumor in Lung from Breast and Thyroid Carcinoma.Cancer research and treatment · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cancer is a disease of extreme heterogeneity. Microarray analysis has identified thousands of genes that are transcriptionally up- or down-regulated in tumor samples; molecularly characterized lesions that play a causative role in tumorigenesis constitute more than 1 percent of the human genome. Such a large number of "cancer genes" stirs the debate of whether it is relevant to continue classifying cancer as a single condition. Yet, a discrete set of cellular processes has been found to underlie such complexity. Their deregulation has been proposed to act as a common denominator that enables tumors to evade cellular barriers to proliferation and metastasis. Efforts have been made to identify and model the mechanistic origins of cancer. Two such models are discussed here: the multistage model of cancer and the cancer platform model. The former suggests cancer arises by the sequential acquisition of mutations leading to the progressive erosion of normal cellular control mechanisms. In contrast, the latter reduces cancer initiation to two interdependent conditions: sustained proliferation with the concomitant inhibition of cell death. This review proposes that a third condition - cellular differentiation - should be added to the cancer platform model. Differentiation can act as a fail-safe mechanism against unrestrained cellular growth - much like cell death. Clinical implications of the different models are also analyzed.
Indexed as
Identifiers
17940619PMC1994802W1716180479What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.