ArticlePloS one2007
Murine gammaherpesvirus-68 inhibits antigen presentation by dendritic cells.
Article in PloS one, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
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- Modulation of Ubiquitin Signaling in Innate Immune Response by Herpesviruses.International journal of molecular sciences · 2022Review
- Immune Control ofViral immunology · 2020Article
- Article
- Gammaherpesvirus Colonization of the Spleen Requires Lytic Replication in B Cells.Journal of virology · 2018Article
- Type I Interferon Signaling to Dendritic Cells Limits Murid Herpesvirus 4 Spread from the Olfactory Epithelium.Journal of virology · 2017Article
- CD8+ T cell evasion mandates CD4+ T cell control of chronic gamma-herpesvirus infection.PLoS pathogens · 2017Article
- Type I Interferons and NK Cells Restrict Gammaherpesvirus Lymph Node Infection.Journal of virology · 2016Article
- Herpes Simplex Virus 1 Interaction with Myeloid Cells In Vivo.Journal of virology · 2016Article
- Does EBV alter the pathogenesis of malaria?Parasite immunology · 2015Review
- Rhadinovirus host entry by co-operative infection.PLoS pathogens · 2015Article
- Defining immune engagement thresholds for in vivo control of virus-driven lymphoproliferation.PLoS pathogens · 2014Article
- BAFF receptor deficiency limits gammaherpesvirus infection.Journal of virology · 2014Article
- Myeloid infection links epithelial and B cell tropisms of Murid Herpesvirus-4.PLoS pathogens · 2012Article
- A heparan-dependent herpesvirus targets the olfactory neuroepithelium for host entry.PLoS pathogens · 2012Article
- Murid herpesvirus-4 exploits dendritic cells to infect B cells.PLoS pathogens · 2011Article
- A mechanistic basis for potent, glycoprotein B-directed gammaherpesvirus neutralization.The Journal of general virology · 2011Article
- Suppression of TLR9 immunostimulatory motifs in the genome of a gammaherpesvirus.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Important role for the murid herpesvirus 4 ribonucleotide reductase large subunit in host colonization via the respiratory tract.Journal of virology · 2010Article
- Vaccination against a hit-and-run viral cancer.The Journal of general virology · 2010Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Dendritic cells (DCs) play a central role in initiating adaptive immunity. Murine gammaherpesvirus-68 (MHV-68), like many persistent viruses, infects DCs during normal host colonization. It therefore provides a means to understanding what host and viral genes contribute to this aspect of pathogenesis. The infected DC phenotype is likely to depend on whether viral gene expression is lytic or latent and whether antigen presentation is maintained. For MHV-68, neither parameter has been well defined. Here we show that MHV-68 infects immature but not mature bone marrow-derived DCs. Infection was predominantly latent and these DCs showed no obvious defect in antigen presentation. Lytically infected DCs were very different. These down-regulated CD86 and MHC class I expression and presented a viral epitope poorly to CD8(+) T cells. Antigen presentation improved markedly when the MHV-68 K3 gene was disrupted, indicating that K3 fulfils an important function in infected DCs. MHV-68 infects only a small fraction of the DCs present in lymphoid tissue, so K3 expression is unlikely to compromise significantly global CD8(+) T cell priming. Instead it probably helps to maintain lytic gene expression in DCs once CD8(+) T cell priming has occurred.
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Registered trials
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