ArticleTetrahedron2007
Total Synthesis of Mycolactones A and B.
Article in Tetrahedron, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- Review
- CryoEM Structure with ATP Synthase Enables Late-Stage Diversification of Cruentaren A.Chemistry (Weinheim an der Bergstrasse, Germany) · 2023Article
- The Sec61 translocon is a therapeutic vulnerability in multiple myeloma.EMBO molecular medicine · 2022Article
- Article
- The chemistry and biology of mycolactones.Beilstein journal of organic chemistry · 2017Review
- Short Convergent Synthesis of the Mycolactone Core Through Lithiation-Borylation Homologations.Chemistry (Weinheim an der Bergstrasse, Germany) · 2015Article
- Accelerated detection of mycolactone production and response to antibiotic treatment in a mouse model of Mycobacterium ulcerans disease.PLoS neglected tropical diseases · 2014Article
- Chemistry of mycolactones, the causative toxins of Buruli ulcer.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Highly stereoselective total synthesis of fully hydroxy-protected mycolactones A and B and their stereoisomerization upon deprotection.Chemistry (Weinheim an der Bergstrasse, Germany) · 2011Article
- Synthesis and structure assignment of the minor metabolite arising from the frog pathogen Mycobacterium liflandii.Tetrahedron letters · 2010Article
- Scalable and efficient synthesis of the mycolactone core.Tetrahedron · 2010Article
- Synthesis and structure of mycolactone E isolated from frog mycobacterium.Organic letters · 2008Article
- Mycolactones: immunosuppressive and cytotoxic polyketides produced by aquatic mycobacteria.Natural product reports · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
First and second generation total syntheses of mycolactones A and B are reported. The first generation total synthesis unambiguously confirmed our earlier assignment of the relative and absolute stereochemistry of mycolactones A and B. Knowledge of the chemical properties of the mycolactones accumulated through the first generation total synthesis allowed us to implement several major improvements to the original synthesis, including: (1) optimizing the choice of protecting groups, (2) eliminating the unnecessary adjustment of protecting groups, and (3) improving the overall stereoselectivity and synthetic efficiency. The second generation total synthesis consists of 21 longest linear steps, with 8.8% overall yield.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.