ArticleBritish journal of cancer2007
Genetic and epigenetic changes in the common 1p36 deletion in neuroblastoma tumours.
Article in British journal of cancer, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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37 citing papers in PubMed, 63 citations in OpenAlex.
- Multi-omics data-based modeling reveals tumorigenesis- and prognosis-associated genes with clinical potential in lung adenocarcinoma.BMC cancer · 2025Article
- Role of the CASZ1 transcription factor in tissue development and disease.European journal of medical research · 2023Review
- Metabolic protein kinase signalling in neuroblastoma.Molecular metabolism · 2023Review
- Review
- Serial Profiling of Circulating Tumor DNA Identifies Dynamic Evolution of Clinically Actionable Genomic Alterations in High-Risk Neuroblastoma.Cancer discovery · 2022Article
- Mig-6 could inhibit cell proliferation and induce apoptosis in esophageal squamous cell carcinoma.Thoracic cancer · 2022Article
- Association between night shift work and methylation of a subset of immune-related genes.Frontiers in public health · 2022Article
- From DNA Copy Number Gains and Tumor Dependencies to Novel Therapeutic Targets for High-Risk Neuroblastoma.Journal of personalized medicine · 2021Review
- Article
- An overview of neuroblastoma cell lineage phenotypes andExperimental biology and medicine (Maywood, N.J.) · 2020Review
- Large 1p36 Deletions Affecting Arid1a Locus Facilitate Mycn-Driven Oncogenesis in Neuroblastoma.Cell reports · 2020Article
- Epigenome-Wide Association Study for All-Cause Mortality in a Cardiovascular Cohort Identifies Differential Methylation in Castor Zinc Finger 1 (Journal of the American Heart Association · 2019Article
- Low UBE4B expression increases sensitivity of chemoresistant neuroblastoma cells to EGFR and STAT5 inhibition.Cancer biology & therapy · 2019Article
- Merkel Cell Carcinoma of the Buccal Mucosa and Lower Lip.Head and neck pathology · 2018Article
- Targeting of epigenetic regulators in neuroblastoma.Experimental & molecular medicine · 2018Review
- Whole exome sequencing identified sixty-five coding mutations in four neuroblastoma tumors.Scientific reports · 2017Article
- Deconvolution of DNA methylation identifies differentially methylated gene regions on 1p36 across breast cancer subtypes.Scientific reports · 2017Article
- Research progress of neuroblastoma related gene variations.Oncotarget · 2017Review
- MIIP haploinsufficiency induces chromosomal instability and promotes tumour progression in colorectal cancer.The Journal of pathology · 2017Article
- The PI3K signaling pathway as a pharmacological target in Autism related disorders and Schizophrenia.Molecular and cellular therapies · 2016Review
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chromosome 1p is frequently deleted in neuroblastoma (NB) tumours. The commonly deleted region has been narrowed down by loss of heterozygosity studies undertaken by different groups. Based on earlier mapping data, we have focused on a region on 1p36 (chr1: 7 765 595-11 019 814) and performed an analysis of 30 genes by exploring features such as epigenetic regulation, that is DNA methylation and histone deacetylation, mutations at the DNA level and mRNA expression. Treatment of NB cell lines with the histone deacetylase inhibitor trichostatin A led to increased gene transcription of four of the 30 genes, ERRFI1 (MIG-6), PIK3CD, RBP7 (CRBPIV) and CASZ1, indicating that these genes could be affected by epigenetic downregulation in NBs. Two patients with nonsynonymous mutations in the PIK3CD gene were detected. One patient harboured three variations in the same exon, and p.R188W. The other patient had the variation p.M655I. In addition, synonymous variations and one variation in an intronic sequence were also found. The mRNA expression of this gene is downregulated in unfavourable, compared to favourable, NBs. One nonsynonymous mutation was also identified in the ERRFI1 gene, p.N343S, and one synonymous. None of the variations above were found in healthy control individuals. In conclusion, of the 30 genes analysed, the PIK3CD gene stands out as one of the most interesting for further studies of NB development and progression.
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