ArticleMammalian genome : official journal of the International Mammalian Genome Society1991
Molecular structure of Tcp-10 genes from the t complex responder locus.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 11 citations in OpenAlex.
- Analysis of Ser/Thr Kinase HASPIN-Interacting Proteins in the Spermatids.International journal of molecular sciences · 2022Article
- Effects of a male meiotic driver on male and female transcriptomes in the house mouse.Proceedings. Biological sciences · 2019Article
- Targeted mutagenesis of a candidate t complex responder gene in mouse t haplotypes does not eliminate transmission ratio distortion.Genetics · 1996Article
- Distortion of transmission ratio by a candidate t complex responder locus transgene.Mammalian genome : official journal of the International Mammalian Genome Society · 1992Article
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2 authors at 1 institution in 1 country.
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Abstract
Male transmission ratio distortion (TRD) is a property of mouse t haplotypes which requires the t complex responder locus (Tcr). Tcr has been localized to a 70-160 kb region in t haplotypes. A candidate gene for the responder, called Tcp-10bt, has been cloned and is one member of a highly related gene family called Tcp-10 (formerly T66). Molecular evidence suggests that unique alternative splicing of the Tcp-10bt gene may be responsible for the mutant responder activity. Here we present the intron/exon structure of a representative Tcp-10 gene, and the characterization of alternative polyadenylation sites. The Tcp-10 genes contain 12 exons which span approximately 21 kb of DNA. At least six different polyadenylation sites are used, and none have a perfect consensus signal. This appears to be a common feature associated with testes-expressed transcripts. Since the gene we have analyzed is absent from many t haplotypes without apparent consequence, and no corresponding cDNAs have been isolated, it was speculated to be a pseudogene. However, no major sequence differences were found within the coding sequence to conclude that Tcp-10pst is a pseudogene.
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