Trial reportBritish journal of cancer2007
The predictive value of molecular markers (p53, EGFR, ATM, CHK2) in multimodally treated squamous cell carcinoma of the oesophagus.
Trial report in British journal of cancer, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed.
- Article
- Review
- High pATM is Associated With Poor Local Control in Supraglottic Cancer Treated With Radiotherapy.The Laryngoscope · 2020Article
- Possible Predictive Markers of Response to Therapy in Esophageal Squamous Cell Cancer.Pathology oncology research : POR · 2019Article
- Impact of alcohol dehydrogenase gene 4 polymorphisms on esophageal squamous cell carcinoma risk in a Chinese population.PloS one · 2015Article
- Is tumor length a prognostic indicator for esophageal squamous cell carcinoma? A single larger study among Chinese patients.International journal of clinical and experimental pathology · 2015Article
- Undervalued criteria in the evaluation of multimodal trials for upper GI cancers.Cancer investigation · 2014Review
- p53 is an independent prognostic factor in operable esophageal squamous cell carcinoma: a large-scale study with a long follow-up.Medical oncology (Northwood, London, England) · 2014Article
- Association of decreased expression of long non-coding RNA LOC285194 with chemoradiotherapy resistance and poor prognosis in esophageal squamous cell carcinoma.Journal of translational medicine · 2014Article
- Current status of predictive biomarkers for neoadjuvant therapy in esophageal cancer.World journal of gastrointestinal pathophysiology · 2014Review
- Correlation of CD146 expression and clinicopathological characteristics in esophageal squamous cell carcinoma.Oncology letters · 2014Article
- Prognostic significance of epidermal growth factor receptor in locally advanced esophageal squamous cell carcinoma for patients receiving chemoradiotherapy.Oncology letters · 2014Article
- Biomarkers for predicting the response of esophageal squamous cell carcinoma to neoadjuvant chemoradiation therapy.Surgery today · 2014Review
- Rad51 expression is a useful predictive factor for the efficacy of neoadjuvant chemoradiotherapy in squamous cell carcinoma of the esophagus.Annals of surgical oncology · 2014Article
- p53 immunohistochemical expression and patient prognosis in esophageal squamous cell carcinoma.Medical oncology (Northwood, London, England) · 2013Article
- The role of ATM and 53BP1 as predictive markers in cervical cancer.International journal of cancer · 2012Article
- Article
- Trimodal therapy in squamous cell carcinoma of the esophagus.European journal of medical research · 2011Article
- The checkpointkinase 2 (CHK2) 1100delC germ line mutation is not associated with the development of squamous cell carcinoma of the head and neck (SCCHN).Journal of negative results in biomedicine · 2010Article
- Early response evaluation and prediction in neoadjuvant-treated patients with esophageal cancer.World journal of gastrointestinal surgery · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pretherapeutic identification of oesophageal squamous cell carcinomas that will respond to neoadjuvant chemoradiotherapy is an important attempt for improvement of patient's prognosis. In the current study, pretherapeutic biopsies from 94 oesophageal squamous cell carcinomas (cT3, cN0/+, cM0) in patients who underwent neoadjuvant chemoradiotherapy (RCTx: 45 Gy plus cisplatin and 5-fluorouracil) and subsequent oesophagectomy in the setting of a single-centre prospective treatment trial were investigated by means of immunohistochemistry. Expression of proteins involved in DNA repair and/or cell-cycle regulation, that is p53, p53 (phosphorylated at Ser15), EGFR, ATM protein kinase (phosphorylated at Ser1981) and checkpoint kinase 2 (CHK2) (phosphorylated at Thr68) was correlated with the response to RCTx and with overall survival. Tumours that were positive for CHK2 expression more frequently showed clinically determined regression after RCTx (69.4%) than tumours that were negative for CHK2 expression (32.1%; P=0.0011), whereas other parameters did not correlate with tumour regression. Expression of ATM correlated with expression of CHK2 (P=0.0061) and p53-phospho (P=0.0064). Expression of p53 correlated with expression of p53-phospho (P<0.0001). In contrast to clinical and histopathological response evaluation, none of the molecular parameters under investigation correlated with overall survival. In conclusion, expression analysis of p53, EGFR CHK2 and ATM has no predictive value in multimodally treated oesophageal squamous cell carcinoma.
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