ArticleProceedings of the National Academy of Sciences of the United States of America2007
Polyphosphate kinase 1, a conserved bacterial enzyme, in a eukaryote, Dictyostelium discoideum, with a role in cytokinesis.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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34 citing papers in PubMed, 71 citations in OpenAlex.
- Identification of a distinct family of polyphosphate kinases relevant to energy homeostasis in Crenarchaeota.The Journal of biological chemistry · 2026Article
- Article
- LucaPCycle: Illuminating microbial phosphorus cycling in deep-sea cold seep sediments using protein language models.Nature communications · 2025Article
- A fusion protein of polyphosphate kinase 1 (PPK1) and a Nudix hydrolase is involved in inorganic polyphosphate accumulation in the unicellular red alga Cyanidioschyzon merolae.Plant molecular biology · 2024Article
- Biomolecular condensates as stress sensors and modulators of bacterial signaling.PLoS pathogens · 2024Review
- The Protein Scaffolding Functions of Polyphosphate.Journal of molecular biology · 2024Review
- Starvation Induces Extracellular Accumulation of Polyphosphate inInternational journal of molecular sciences · 2023Article
- Model systems for studying polyphosphate biology: a focus on microorganisms.Current genetics · 2021Review
- Did Cyclic Metaphosphates Have a Role in the Origin of Life?Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life · 2021Review
- Inorganic polyphosphate as an energy source in tumorigenesis.Oncotarget · 2020Article
- [A fluorometric method for direct detection of inorganic polyphosphate in enterohemorrhagicNan fang yi ke da xue xue bao = Journal of Southern Medical University · 2019Article
- Inorganic polyphosphate, a multifunctional polyanionic protein scaffold.The Journal of biological chemistry · 2019Review
- Polyphosphate granule biogenesis is temporally and functionally tied to cell cycle exit during starvation inProceedings of the National Academy of Sciences of the United States of America · 2017Article
- Extracellular Polyphosphate Inhibits Proliferation in an Autocrine Negative Feedback Loop in Dictyostelium discoideum.The Journal of biological chemistry · 2016Article
- Acidocalcisomes of eukaryotes.Current opinion in cell biology · 2016Review
- Polyphosphate and acidocalcisomes.Biochemical Society transactions · 2016Review
- Inorganic polyphosphate in the microbial world. Emerging roles for a multifaceted biopolymer.World journal of microbiology & biotechnology · 2016Review
- Developmental accumulation of inorganic polyphosphate affects germination and energetic metabolism in Dictyostelium discoideum.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Protein quality control under oxidative stress conditions.Journal of molecular biology · 2015Review
- Transcriptome analysis of Campylobacter jejuni polyphosphate kinase (ppk1 and ppk2) mutants.Virulence · 2015Article
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5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Polyphosphate kinase 1 (PPK1), the principal enzyme responsible for reversible synthesis of polyphosphate (poly P) from the terminal phosphate of ATP, is highly conserved in bacteria and archaea. Dictyostelium discoideum, a social slime mold, is one of a few eukaryotes known to possess a PPK1 homolog (DdPPK1). Compared with PPK1 of Escherichia coli, DdPPK1 contains the conserved residues for ATP binding and autophosphorylation, but has an N-terminal extension of 370 aa, lacking homology with any known protein. Polyphosphate or ATP promote oligomerization of the enzyme in vitro. The DdPPK1 products are heterogeneous in chain length and shorter than those of E. coli. The unique DdPPK1 N-terminal domain was shown to be necessary for its enzymatic activity, cellular localization, and physiological functions. Mutants of DdPPK1, as previously reported, are defective in development, sporulation, and predation, and as shown here, in late stages of cytokinesis and cell division.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.