ArticleProceedings of the National Academy of Sciences of the United States of America2007
The other side of the nearly neutral theory, evidence of slightly advantageous back-mutations.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed.
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- In silico prediction of variant effects: promises and limitations for precision plant breeding.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Review
- Whole-genome relaxed selection and molecular constraints in Triplophysa under adapted Qinghai-Tibetan Plateau.BMC genomics · 2025Article
- Estimating the proportion of beneficial mutations that are not adaptive in mammals.PLoS genetics · 2024Article
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- Reversions mask the contribution of adaptive evolution in microbiomes.bioRxiv : the preprint server for biology · 2024Article
- Increased Positive Selection in Highly Recombining Genes Does not Necessarily Reflect an Evolutionary Advantage of Recombination.Molecular biology and evolution · 2024Article
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- Novel genome sequence of Chinese cavefish (Triplophysa rosa) reveals pervasive relaxation of natural selection in cavefish genomes.Molecular ecology · 2022Article
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- Does effective population size affect rates of molecular evolution: Mitochondrial data for host/parasite species pairs in bees suggests not.Ecology and evolution · 2022Article
- Selection on Accessible Chromatin Regions in Capsella grandiflora.Molecular biology and evolution · 2021Article
- Revisiting the notion of deleterious sweeps.Genetics · 2021Article
- Bridgehead effect and multiple introductions shape the global invasion history of a termite.Communications biology · 2021Article
- Crossing fitness valleys via double substitutions within codons.BMC biology · 2019Article
- Comparison of the Full Distribution of Fitness Effects of New Amino Acid Mutations Across Great Apes.Genetics · 2019Article
- Increase in viability due to the accumulation of X chromosome mutations in Drosophila melanogaster males.Genetica · 2018Article
- Inference of Distribution of Fitness Effects and Proportion of Adaptive Substitutions from Polymorphism Data.Genetics · 2017Article
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2 authors.
Funding
Abstract
We argue that if there is a category of slightly deleterious mutations, then there should be a category of slightly advantageous back-mutations. We show that when there are both slightly deleterious and advantageous back-mutations, there is likely to be an increase in the rate of evolution after a population size expansion. This increase in the rate of evolution is short-lived. However, we show how its signature can be captured by comparing the rate of evolution in species that have undergone population size expansion versus contraction. We test our model by comparing the pattern of evolution in pairs of island and mainland species in which the colonization event was either island-to-mainland (population size expansion) or mainland-to-island (contraction). We show that the predicted pattern of evolution is observed.
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