ArticleProceedings of the National Academy of Sciences of the United States of America2007
Demethylation of a specific hypersensitive site in the Th2 locus control region.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 70 citations in OpenAlex.
- T-follicular helper cells are epigenetically poised to transdifferentiate into T-regulatory type 1 cells.eLife · 2024Article
- Regulation of T helper cell differentiation by the interplay between histone modification and chromatin interaction.Immunity · 2024Article
- Transcriptional re-programming of liver-resident iNKT cells into T-regulatory type-1-like liver iNKT cells involves extensive gene de-methylation.Frontiers in immunology · 2024Article
- Targeted DNA Demethylation: Vectors, Effectors and Perspectives.Biomedicines · 2023Review
- DNA Methylation in T-Cell Development and Differentiation.Critical reviews in immunology · 2020Review
- Transcription factor Oct1 protects against hematopoietic stress and promotes acute myeloid leukemia.Experimental hematology · 2019Article
- Exposure of Human CD8Frontiers in immunology · 2018Article
- The environment, epigenome, and asthma.The Journal of allergy and clinical immunology · 2017Review
- The nasal methylome and childhood atopic asthma.The Journal of allergy and clinical immunology · 2017Article
- Article
- BATF Modulates the Th2 Locus Control Region and Regulates CD4+ T Cell Fate during Antihelminth Immunity.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- T helper 2 and T follicular helper cells: Regulation and function of interleukin-4.Cytokine & growth factor reviews · 2016Review
- Review
- Transcriptional and epigenetic networks of helper T and innate lymphoid cells.Immunological reviews · 2014Review
- Establishment of active chromatin structure at enhancer elements by mixed-lineage leukemia 1 to initiate estrogen-dependent gene expression.Nucleic acids research · 2014Article
- Epigenetic regulation of asthma and allergic disease.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2014Review
- 'All things considered': transcriptional regulation of T helper type 2 cell differentiation from precursor to effector activation.Immunology · 2013Review
- Hypersensitive site 6 of the Th2 locus control region is essential for Th2 cytokine expression.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Transcription factor YY1 is essential for regulation of the Th2 cytokine locus and for Th2 cell differentiation.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Epigenetic control of cytokine gene expression: regulation of the TNF/LT locus and T helper cell differentiation.Advances in immunology · 2013Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A growing body of literature has examined and implicated DNA methylation as a critical epigenetic modification in T helper (Th) cell differentiation. The absence of DNA methyltransferases or methyl-binding proteins derepresses many cytokine loci, allowing their ectopic expression, while methylation of specific CpG residues is sufficient to prevent expression. Here, we characterize demethylation events of the Th2 cytokine locus control region (LCR). rad50 hypersensitive site 7 (RHS7), a hypersensitive site within this LCR, becomes demethylated in a STAT6-dependent manner and only in cells stimulated under type 2 conditions. Robust demethylation appears to require signaling contributions from both IL-4 receptor, via STAT6, and CD28, but it cannot be effected by GATA3. Finally, RHS7 is demethylated independently of cell division, consistent with an "active," rather than passive, mechanism. Taken together, these findings firmly connect RHS7 demethylation and Th2 LCR activation in the type 2 differentiation program.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.