ArticleProceedings of the National Academy of Sciences of the United States of America2007
Antagonistic pleiotropic effects reduce the potential adaptive value of the FRIGIDA locus.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed, 105 citations in OpenAlex.
- Genetic basis of temporal variation in phenology in a woody perennial plant.NPJ systems biology and applications · 2026Article
- Stochastic phenotypic switching arises in response to directional selection in experimentally evolved multicellular yeast.Communications biology · 2025Article
- Epistasis and pleiotropy-induced variation for plant breeding.Plant biotechnology journal · 2024Review
- Pleiotropy alleviates the fitness costs associated with resource allocation trade-offs in immune signalling networks.Proceedings. Biological sciences · 2024Article
- Identification of superior haplotypes for flowering time in pigeonpea through candidate gene-based association study of a diverse minicore collection.Plant cell reports · 2024Article
- Pleiotropy alleviates the fitness costs associated with resource allocation trade-offs in immune signaling networks.bioRxiv : the preprint server for biology · 2023Article
- A Pleiotropic Flowering Time QTL Exhibits Gene-by-Environment Interaction for Fitness in a Perennial Grass.Molecular biology and evolution · 2022Article
- The influence of genetic architecture on responses to selection under drought in rice.Evolutionary applications · 2022Article
- A B73×Palomero Toluqueño mapping population reveals local adaptation in Mexican highland maize.G3 (Bethesda, Md.) · 2022Article
- Article
- Mapping the adaptive landscape of a major agricultural pathogen reveals evolutionary constraints across heterogeneous environments.The ISME journal · 2021Article
- Multi-parent populations in crops: a toolbox integrating genomics and genetic mapping with breeding.Heredity · 2020Review
- A Nested Association Mapping Panel inG3 (Bethesda, Md.) · 2020Article
- Adaptation via pleiotropy and linkage: Association mapping reveals a complex genetic architecture within the sticklebackEvolution letters · 2020Article
- The evolution of metabolism: How to test evolutionary hypotheses at the genomic level.Computational and structural biotechnology journal · 2020Review
- Natural variation in Arabidopsis shoot branching plasticity in response to nitrate supply affects fitness.PLoS genetics · 2019Article
- Article
- Natural variation in life history strategy of Arabidopsis thaliana determines stress responses to drought and insects of different feeding guilds.Molecular ecology · 2017Article
- Epistatic and allelic interactions control expression of ribosomal RNA gene clusters in Arabidopsis thaliana.Genome biology · 2017Article
- Pleiotropy, constraint, and modularity in the evolution of life histories: insights from genomic analyses.Annals of the New York Academy of Sciences · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although the occurrence of epistasis and pleiotropy is widely accepted at the molecular level, its effect on the adaptive value of fitness-related genes is rarely investigated in plants. Knowledge of these features of a gene is critical to understand the molecular basis of adaptive evolution. Here we investigate the importance of pleiotropy and epistasis in determining the adaptive value of a candidate gene using the gene FRI (FRIGIDA), which is thought to be the major gene controlling flowering time variation in Arabidopsis thaliana. The effect of FRI on flowering time was analyzed in an outbred population created by randomly mating 19 natural accessions of A. thaliana. This unique population allows the estimation of FRI effects independent of any linkage association with other loci due to demographic processes or to coadapted genes. It also allows for the estimation of pleiotropic effects of FRI on fitness and inflorescence architecture. We found that FRI explains less variation in flowering time than previously observed among natural accessions, and interacts epistatically with the FLC locus. Although early flowering plants produce more fruits under spring conditions, and nonfunctional alleles of FRI were associated with early flowering, variation at FRI was not associated with fitness. We show that nonfunctional FRI alleles have negative pleiotropic effects on fitness by reducing the numbers of nodes and branches on the inflorescence. We propose that these antagonistic pleiotropic effects reduce the adaptive value of FRI, and helps explain the maintenance of alternative life history strategies across natural populations of A. thaliana.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.