ArticleProceedings of the National Academy of Sciences of the United States of America2007
The basic helix loop helix domain of maize R links transcriptional regulation and histone modifications by recruitment of an EMSY-related factor.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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47 citing papers in PubMed, 90 citations in OpenAlex.
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- Two mutations in the same MYC-bHLH transcription factor cause segregation of purple coloration of stolons and seed heads inHorticulture research · 2025Article
- Current Status and Advances in Anti-Androgen Therapy for Triple-Negative Breast Cancer.Current medical science · 2025Review
- Molecular Control of Flower Colour Change in Angiosperms.Plants (Basel, Switzerland) · 2025Review
- Regulation of Flavonoid Biosynthesis by the MYB-bHLH-WDR (MBW) Complex in Plants and Its Specific Features in Cereals.International journal of molecular sciences · 2025Review
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- Genome-wide identification of bHLH transcription factors and expression analysis under drought stress inPhysiology and molecular biology of plants : an international journal of functional plant biology · 2024Article
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- A regulatory loop establishes the link between the circadian clock and abscisic acid signaling in rice.Plant physiology · 2023Article
- Genome-wide identification of bHLH transcription factors and their response to salt stress inFrontiers in plant science · 2023Article
- Maize Flavonoid Biosynthesis, Regulation, and Human Health Relevance: A Review.Molecules (Basel, Switzerland) · 2022Review
- Genome-Wide Identification of Apple Atypical bHLH Subfamily PRE Members and Functional Characterization of MdPRE4.3 in Response to Abiotic Stress.Frontiers in genetics · 2022Article
- Multilevel regulation of anthocyanin-promoting R2R3-MYB transcription factors in plants.Frontiers in plant science · 2022Review
- Genome-wide characterization and analysis of bHLH transcription factors related to anthocyanin biosynthesis in spine grapes (Vitis davidii).Scientific reports · 2021Article
- Linking anthocyanin diversity, hue, and genetics in purple corn.G3 (Bethesda, Md.) · 2021Article
- Anthocyanins: From Mechanisms of Regulation in Plants to Health Benefits in Foods.Frontiers in plant science · 2021Review
- Skin Color in Apple Fruit (Epigenomes · 2020Review
- Mapping Regulatory Determinants in Plants.Frontiers in genetics · 2020Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The control of anthocyanin accumulation in maize by the cooperation of the basic helix-loop-helix (bHLH) protein R with the MYB transcription factor C1 provides one of the best examples of plant combinatorial transcriptional control. Establishing the function of the bHLH domain of R has remained elusive, and so far no proteins that interact with this conserved domain have been identified. We show here that the bHLH domain of R is dispensable for the activation of transiently expressed genes yet is essential for the activation of the endogenous genes in their normal chromatin environment. The activation of A1, one of the anthocyanin biosynthetic genes, is associated with increased acetylation of histone 3 (H3) at K9/K14 in the promoter region to which the C1/R complex binds. We identified R-interacting factor 1 (RIF1) as a nuclear, AGENET domain-containing EMSY-like protein that specifically interacts with the bHLH region of R. Knockdown experiments show that RIF1 is necessary for the activation of the endogenous promoters but not of transiently expressed genes. ChIP experiments established that RIF1 is tethered to the regulatory region of the A1 promoter by the C1/R complex. Together, these findings describe a function for the bHLH domain of R in linking transcriptional regulation with chromatin functions by the recruitment of an EMSY-related factor.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.