ArticleProceedings of the National Academy of Sciences of the United States of America2007
Proteomic identification of tmRNA substrates.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 30 citations in OpenAlex.
- The regulation of AsfR on tmRNA expression mediates bacterial motility and virulence inVirulence · 2026Article
- Cooperative and Independent Functionality of tmRNA and SmpB inInternational journal of molecular sciences · 2025Article
- Physiology of trans-translation deficiency in Bacillus subtilis - a comparative proteomics study.Proteomics · 2023Article
- Peptide Aptamer PA3 Attenuates the Viability ofFrontiers in microbiology · 2022Article
- Applications of Bacterial Degrons and Degraders - Toward Targeted Protein Degradation in Bacteria.Frontiers in molecular biosciences · 2021Review
- CauloBrowser: A systems biology resource for Caulobacter crescentus.Nucleic acids research · 2016Article
- Resolving nonstop translation complexes is a matter of life or death.Journal of bacteriology · 2014Review
- Post-translational regulation via Clp protease is critical for survival of Mycobacterium tuberculosis.PLoS pathogens · 2014Article
- tmRNA-mediated trans-translation as the major ribosome rescue system in a bacterial cell.Frontiers in genetics · 2014Review
- Identification of ClpP substrates in Caulobacter crescentus reveals a role for regulated proteolysis in bacterial development.Molecular microbiology · 2013Article
- The tmRNA ribosome-rescue system.Advances in protein chemistry and structural biology · 2012Review
- Article
- Beyond ribosome rescue: tmRNA and co-translational processes.FEBS letters · 2010Review
- Significant bias against the ACA triplet in the tmRNA sequence of Escherichia coli K-12.Journal of bacteriology · 2009Article
- Control and benefits of CP4-57 prophage excision in Escherichia coli biofilms.The ISME journal · 2009Article
- Controlled degradation by ClpXP protease tunes the levels of the excision repair protein UvrA to the extent of DNA damage.Molecular microbiology · 2009Article
- Complex regulatory pathways coordinate cell-cycle progression and development in Caulobacter crescentus.Advances in microbial physiology · 2009Review
- Evolution of the ssrA degradation tag in Mycoplasma: specificity switch to a different protease.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The tmRNA-SmpB system releases ribosomes stalled on truncated mRNAs and tags the nascent polypeptides to target them for proteolysis. In many species, mutations that disrupt tmRNA activity cause defects in growth or development. In Caulobacter crescentus cells lacking tmRNA activity there is a delay in the initiation of DNA replication, which disrupts the cell cycle. To understand the molecular basis for this phenotype, 73 C. crescentus proteins were identified that are tagged by tmRNA under normal growth conditions. Among these substrates, proteins involved in DNA replication, recombination, and repair were overrepresented, suggesting that misregulation of these factors in the absence of tmRNA activity might be responsible for the delay in initiation of DNA replication. Analysis of the tagging sites within these substrates revealed a conserved nucleotide motif 5' of the tagging site, which is required for wild-type tmRNA tagging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.