ArticleProceedings. Biological sciences2007
Quasi-species evolution in subdivided populations favours maximally deleterious mutations.
Article in Proceedings. Biological sciences, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed, 14 citations in OpenAlex.
- Why are viral genomes so fragile? The bottleneck hypothesis.PLoS computational biology · 2021Article
- Adapting the engine to the fuel: mutator populations can reduce the mutational load by reorganizing their genome structure.BMC evolutionary biology · 2019Article
- The relationship between the error catastrophe, survival of the flattest, and natural selection.BMC evolutionary biology · 2011Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Most models of quasi-species evolution predict that populations will evolve to occupy areas of sequence space with the greatest concentration of neutral sequences, thus minimizing the deleterious mutation rate and creating mutationally 'robust' genomes. In contrast, empirical studies of the principal model of quasi-species evolution, RNA viruses, suggest that the effects of deleterious mutations are more severe than in similar DNA-based microbes. We demonstrate that populations divided into discrete patches connected by dispersal may favour genotypes where the deleterious effect of non-neutral mutations is maximized. This effect is especially strong in the absence of back mutation and when the amount of time spent in hosts prior to dispersal is intermediate. Our results indicate that RNA viruses that produce acute infections initiated by a small number of virions are expected to evolve fragile genetic architectures when compared with other RNA viruses.
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Registered trials
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