ArticleBMC evolutionary biology2007
Birth and death of gene overlaps in vertebrates.
Article in BMC evolutionary biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 36 citations in OpenAlex.
- Genome-wide comparative analysis reveals distinct evolutionary patterns of overlapping genes in prokaryotes and eukaryotes.Heredity · 2026Article
- Mechanism of expression regulation of head-to-head overlapping protein-coding genes INO80E and HIRIP3.Communications biology · 2025Article
- Overlaps Between CDS Regions of Protein-Coding Genes in the Human Genome: A Case Study on the NR1D1-THRA Gene Pair.Journal of molecular evolution · 2023Article
- Article
- Promoter switching in response to changing environment and elevated expression of protein-coding genes overlapping at their 5' ends.Scientific reports · 2021Article
- OLGenie: Estimating Natural Selection to Predict Functional Overlapping Genes.Molecular biology and evolution · 2020Article
- Characterization of Simple Sequence Repeats (SSRs) in Ciliated Protists Inferred by Comparative Genomics.Microorganisms · 2020Article
- De novo gene birth.PLoS genetics · 2019Article
- The Evolution and Expression Pattern of Human Overlapping lncRNA and Protein-coding Gene Pairs.Scientific reports · 2017Article
- De Novo Genes Arise at a Slow but Steady Rate along the Primate Lineage and Have Been Subject to Incomplete Lineage Sorting.Genome biology and evolution · 2016Article
- Overlapping Regions in HIV-1 Genome Act as Potential Sites for Host-Virus Interaction.Frontiers in microbiology · 2016Article
- Overlapping genes: a new strategy of thermophilic stress tolerance in prokaryotes.Extremophiles : life under extreme conditions · 2015Article
- Origin and length distribution of unidirectional prokaryotic overlapping genes.G3 (Bethesda, Md.) · 2014Article
- Successful COG8 and PDF overlap is mediated by alterations in splicing and polyadenylation signals.Human genetics · 2012Article
- De novo origin of protein-coding genes in murine rodents.PloS one · 2012Article
- Evolutionary origins of Brassicaceae specific genes in Arabidopsis thaliana.BMC evolutionary biology · 2011Article
- Structure and expression of two nuclear receptor genes in marsupials: insights into the evolution of the antisense overlap between the α-thyroid hormone receptor and Rev-erbα.BMC molecular biology · 2010Article
- Recent de novo origin of human protein-coding genes.Genome research · 2009Article
- Origins of gonadotropin-releasing hormone (GnRH) in vertebrates: identification of a novel GnRH in a basal vertebrate, the sea lamprey.Endocrinology · 2008Article
- A method for the simultaneous estimation of selection intensities in overlapping genes.PloS one · 2008Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBetween five and fourteen per cent of genes in the vertebrate genomes do overlap sharing some intronic and/or exonic sequence. It was observed that majority of these overlaps are not conserved among vertebrate lineages. Although several mechanisms have been proposed to explain gene overlap origination the evolutionary basis of these phenomenon are still not well understood. Here, we present results of the comparative analysis of several vertebrate genomes. The purpose of this study was to examine overlapping genes in the context of their evolution and mechanisms leading to their origin.
resultsBased on the presence and arrangement of human overlapping genes orthologs in rodent and fish genomes we developed 15 theoretical scenarios of overlapping genes evolution. Analysis of these theoretical scenarios and close examination of genomic sequences revealed new mechanisms leading to the overlaps evolution and confirmed that many of the vertebrate gene overlaps are not conserved. This study also demonstrates that repetitive elements contribute to the overlapping genes origination and, for the first time, that evolutionary events could lead to the loss of an ancient overlap.
conclusionBirth as well as most probably death of gene overlaps occurred over the entire time of vertebrate evolution and there wasn't any rapid origin or 'big bang' in the course of overlapping genes evolution. The major forces in the gene overlaps origination are transposition and exaptation. Our results also imply that origin of overlapping genes is not an issue of saving space and contracting genomes size.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.