ArticleDiagnostic pathology2007
A unique RET EXON 11 (G691S) polymorphism in an Indian patient with a collision tumor of the thyroid.
Article in Diagnostic pathology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Haplotype Frequency of G691S/S904S in the RET Proto-Onco-gene in Patients with Medullary Thyroid Carcinoma.Iranian journal of public health · 2014Article
- Merged histological types of malignant thyroid tumor: experience and controversy.Medical oncology (Northwood, London, England) · 2012Article
- RET gene mutations and polymorphisms in medullary thyroid carcinomas in Indian patients.Journal of biosciences · 2011Article
- Intrathyroidal parathyroid carcinoma: a case report with clinical and histological findings.Diagnostic pathology · 2008Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCollision tumors of the thyroid are rare, with occasional reports dealing with their genetic analysis. CASE PRESENTATION: A 59 year old lady presented with a neck mass, associated with hoarseness of voice of 5 years duration. Radiological examination revealed nodular masses in the left lobe of her thyroid, along with one in the isthmus, extending into the right lobe and associated with enlarged neck nodes. FNAC from the left thyroid showed features of medullary carcinoma. On total thyroidectomy, 2 distinct tumor nodules were identified in the left lobe with another in the isthmus, showing features of medullary carcinoma (MTC), papillary carcinoma and follicular variant of papillary carcinoma, respectively, accompanied with nodal metastasis. Subsequently, she underwent radioablation. RET gene analysis of the patient, her 2 daughters and a grandson revealed a unique G691S polymorphism on Exon 11.
conclusionThis unique case of a collision tumor of thyroid, including component of an MTC deals with the value of RET gene analysis and therapeutic implications in the index case and in family members.
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