ArticleDigestive diseases and sciences2008
cagA gene and protein status among Iranian Helicobacter pylori strains.
Article in Digestive diseases and sciences, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association of Helicobacter pylori vacA genotypes and peptic ulcer in Iranian population: a systematic review and meta-analysis.BMC gastroenterology · 2020Pooled it
- The immunopathogenesis ofFrontiers in microbiology · 2024Review
- Helicobacter Pylori infection among Iranian patients with normal upper gastrointestinal endoscopy.Caspian journal of internal medicine · 2022Article
- Reciprocal impact of host factors and Helicobacter pylori genotypes on gastric diseases.World journal of gastroenterology · 2015Article
- Association Between Helicobacter pylori cagA, babA2 Virulence Factors and Gastric Mucosal Interleukin-33 mRNA Expression and Clinical Outcomes in Dyspeptic Patients.International journal of molecular and cellular medicine · 2015Article
- Clinical relevance of cagL gene and virulence genotypes with disease outcomes in a Helicobacter pylori infected population from Iran.World journal of microbiology & biotechnology · 2014Article
- CagA and VacA genotypes in peptic ulcer disease and non-ulcer dyspepsia: a case-control study.Medical journal of the Islamic Republic of Iran · 2014Article
- Association between Helicobacter pylori, cagA, and vacA Status and Clinical Presentation in Iranian Children.Iranian journal of pediatrics · 2013Article
- Low frequency of cagA-positive Helicobacter pylori strains isolated from Iranian patients with MALT lymphoma.Internal and emergency medicine · 2013Article
- Diversity of Helicobacter Pylori cagA and vacA Genes and Its Relationship with Clinical Outcomes in Azerbaijan, Iran.Advanced pharmaceutical bulletin · 2013Article
- Study of Helicobacter pylori genotype status in saliva, dental plaques, stool and gastric biopsy samples.World journal of gastroenterology · 2012Article
- Helicobacter pylori in Iran: A systematic review on the association of genotypes and gastroduodenal diseases.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2012Article
- cagA and vacA status and influence of Helicobacter pylori infection on serum oxidative DNA damage in Iranian patients with peptic ulcer disease.Irish journal of medical science · 2011Article
- Clinical Validation of an Office-Based C-UBT (Heliprobe) for H. pylori Diagnosis in Iranian Dyspeptic Patients.Gastroenterology research and practice · 2011Article
- Analysis of Helicobacter pylori genotypes in Afghani and Iranian isolates.Polish journal of microbiology · 2010Article
- Determination of Helicobacter pylori virulence by analysis of the cag pathogenicity island isolated from Iranian patients.Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver · 2009Article
- Distribution of Helicobacter pylori cagA, cagE, oipA and vacA in different major ethnic groups in Tehran, Iran.Journal of gastroenterology and hepatology · 2009Article
- The distribution of cagA and dupA genes in Helicobacter pylori strains in Kurdistan region, northern Iraq.Annals of Saudi medicineArticle
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The wide geographic genetic diversity of Helicobacter pylori (Hp) and, in particular, the varying prevalence of cagA in different countries has been documented repeatedly. This study was designed to determine the frequency of cagA in Iranian Hp strains by means of genotyping and assessment of host antibodies. Helicobacter pylori strains from 235 patients, including 174 non-ulcer dyspepsia, 25 peptic ulcer and 36 gastric cancer patients, were studied. The frequencies of the 5', middle and 3' terminal regions of the cagA gene were 90.6, 57.6, 89%, respectively, with no correlation to the clinical outcomes. Antibodies against the CagA protein were present in 90.7% of patients. Multiple biopsy sampling in 97 cases revealed multiple infection in 16.5% of the patients. Sequencing of the seven variants of the 3' end of the cagA gene revealed no clustering and the distribution of the Iranian strains among those of other countries. Our results from the genotyping and serology analyses confirm that the majority of Iranian Hp strains are cagA-positive.
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