ArticleHistochemistry and cell biology2008
Generation and analysis of Elf5-LacZ mouse: unique and dynamic expression of Elf5 (ESE-2) in the inner root sheath of cycling hair follicles.
Article in Histochemistry and cell biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 21 citations in OpenAlex.
- The involvement of Elf5 in regulating keratinocyte proliferation and differentiation processes in skin.PloS one · 2025Article
- Genetic Study of Elf5 and Ehf in the Mouse Salivary Gland.Journal of dental research · 2023Article
- Hair Follicle-Related MicroRNA-34a Serum Expression and rs2666433A/G Variant in Patients with Alopecia: A Cross-Sectional Analysis.Biomolecules · 2022Article
- Loss of ELF5-FBXW7 stabilizes IFNGR1 to promote the growth and metastasis of triple-negative breast cancer through interferon-γ signalling.Nature cell biology · 2020Article
- A new Elf5FEBS letters · 2019Article
- ELF3, ELF5, EHF and SPDEF Transcription Factors in Tissue Homeostasis and Cancer.Molecules (Basel, Switzerland) · 2018Review
- Elf5 is a principal cell lineage specific transcription factor in the kidney that contributes to Aqp2 and Avpr2 gene expression.Developmental biology · 2017Article
- Elf5 regulates mammary gland stem/progenitor cell fate by influencing notch signaling.Stem cells (Dayton, Ohio) · 2012Article
- Glucocorticoid receptor regulates overlapping and differential gene subsets in developing and adult skin.Molecular endocrinology (Baltimore, Md.) · 2010Article
- Abnormal hair follicle development and altered cell fate of follicular keratinocytes in transgenic mice expressing DeltaNp63alpha.Development (Cambridge, England) · 2010Article
- Extending the knowledge in histochemistry and cell biology.Histochemistry and cell biology · 2010Review
- State-of-the-art technologies, current opinions and developments, and novel findings: news from the field of histochemistry and cell biology.Histochemistry and cell biology · 2008Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The Elf5/ESE-2 transcription factor is a member of the Epithelium Specific Ets subfamily of Ets transcription factors. Expression of Elf5 has been known to be restricted to organs and tissues rich in glandular or secretory epithelial cells such as kidney and mammary gland as well as differentiated keratinocytes of the skin. We have engineered an Elf5-LacZ mouse strain in which the bulk of the coding region of the Elf5 gene has been replaced by the beta-galactosidase (LacZ) reporter gene and the neomycin resistance cassette. We show here that LacZ gene expression in Elf5-LacZ mice occurs in spatial and temporal patterns that mimic endogenous Elf5 expression as observed by strong X-Gal staining in the mammary luminal epithelial cells of heterozygous Elf5-LacZ animals. Our analysis also reveals previously undiscovered expression site for Elf5 in the differentiated cells of the inner root sheath of hair follicle. The generation of a novel Elf5 gene targeted mouse model harboring a LacZ reporter gene provides an advantage for in vivo studies of Elf5 due to the highly sensitive and easy in situ detection of LacZ gene expression through histochemical staining with X-Gal. Taken together, this study brings new insights into novel patterns of Elf5 expression likely correlating with functionally important control in hair follicle cycle.
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