Trial reportEnvironmental health perspectives2007
The contribution of dental amalgam to urinary mercury excretion in children.
Trial report in Environmental health perspectives, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00066118 (The Casa Pia Study of the Health Effects of Dental Amalgam in Children.), which is not on this map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Casa Pia Study of the Health Effects of Dental Amalgam in Children.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.
- Direct composite resin fillings versus amalgam fillings for permanent posterior teeth.The Cochrane database of systematic reviews · 2021Pooled it
- Dental amalgam exposure and urinary mercury levels in children: the New England Children's Amalgam Trial.Environmental health perspectives · 2008Trial
- Modification of neurobehavioral effects of mercury by a genetic polymorphism of coproporphyrinogen oxidase in children.Neurotoxicology and teratologyTrial
- Modification of neurobehavioral effects of mercury by genetic polymorphisms of metallothionein in children.Neurotoxicology and teratologyTrial
- Correlation between dental amalgam fillings and urinary mercury levels in the Jordanian population: A comparative population-based study.Journal of dental sciences · 2026Article
- The Impact of Mercury from Dental Amalgams on Pregnancy and Childhood: A Health and Risk Assessment Evaluation.Current medicinal chemistry · 2025Review
- Association between dental amalgam restoration and urine mercury concentrations among young women: a cross-sectional study.Journal of Yeungnam medical science · 2023Article
- Biomonitoring of toxic metals, organochlorine pesticides, and polybrominated biphenyl 153 in Michigan urban anglers.Environmental research · 2022Article
- Total blood mercury and its determinants in New Zealand children and adults.Journal of exposure science & environmental epidemiology · 2021Article
- Urinary Mercury Levels and Predictors of Exposure among a Group of Italian Children.International journal of environmental research and public health · 2020Article
- Clinical Effects of Mercury in Conservative Dentistry: A Systematic Review, Meta-Analysis, and Trial Sequential Analysis of Randomized Controlled Trials.International journal of dentistry · 2020Review
- Levels of Mercury in Fish-Eating Children, With and Without Amalgam Restoration.Journal of pharmacy & bioallied sciences · 2019Article
- Application of linear mixed-effects model with LASSO to identify metal components associated with cardiac autonomic responses among welders: a repeated measures study.Occupational and environmental medicine · 2017Article
- Mercury in Children: Current State on Exposure through Human Biomonitoring Studies.International journal of environmental research and public health · 2017Review
- Dental amalgam exposure can elevate urinary mercury concentrations in children.International dental journal · 2016Article
- Genetic polymorphisms affecting susceptibility to mercury neurotoxicity in children: summary findings from the Casa Pia Children's Amalgam clinical trial.Neurotoxicology · 2014Article
- Genetic polymorphisms of catechol-O-methyltransferase modify the neurobehavioral effects of mercury in children.Journal of toxicology and environmental health. Part A · 2014Article
- The dental amalgam toxicity fear: a myth or actuality.Toxicology international · 2012Article
- Biocompatibility of dental amalgams.International journal of dentistry · 2011Article
- Nephrotoxicity, neurotoxicity, and mercury exposure among children with and without dental amalgam fillings.International journal of hygiene and environmental health · 2009Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundUrinary mercury concentrations are widely used as a measure of mercury exposure from dental amalgam fillings. No studies have evaluated the relationship of these measures in a longitudinal context in children.
objectiveWe evaluated urinary mercury in children 8-18 years of age in relation to number of amalgam surfaces and time since placement over a 7-year course of amalgam treatment.
methodsFive hundred seven children, 8-10 years of age at baseline, participated in a clinical trial to evaluate the neurobehavioral effects of dental amalgam in children. Subjects were randomized to either dental amalgam or resin composite treatments. Urinary mercury and creatinine concentrations were measured at baseline and annually on all participants.
resultsTreatment groups were comparable in baseline urinary mercury concentration (approximately 1.5 microg/L). Mean urinary mercury concentrations in the amalgam group increased to a peak of approximately 3.2 microg/L at year 2 and then declined to baseline levels by year 7 of follow-up. There was a strong, positive association between urinary mercury and both number of amalgam surfaces and time since placement. Girls had significantly higher mean urinary mercury concentrations than boys throughout the course of amalgam treatment. There were no differences by race in urinary mercury concentration associated with amalgam exposure.
conclusionsUrinary mercury concentrations are highly correlated with both number of amalgam fillings and time since placement in children. Girls excrete significantly higher concentrations of mercury in the urine than boys with comparable treatment, suggesting possible sex-related differences in mercury handling and susceptibility to mercury toxicity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.