ArticleEnvironmental health perspectives2007
Case report: mixed cholestatic/hepatocellular liver injury induced by the herbicide quizalofop-p-ethyl.
Article in Environmental health perspectives, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Potential Hepatotoxins Found in Herbal Medicinal Products: A Systematic Review.International journal of molecular sciences · 2020Pooled it
- Pesticide-related fatalities referred for diagnostic difficulty: a forensic case series highlighting scene-toxicology discordance.Forensic science, medicine, and pathology · 2026Article
- A human liver organoid platform for hepatotoxicity assessment: evaluation using reference compounds.Frontiers in toxicology · 2026Article
- Mechanistic Insight into the Enantioselective Degradation of Esterase QeH to (International journal of molecular sciences · 2024Article
- The Genome Analysis ofInternational journal of molecular sciences · 2020Article
- Nanometer Titanium Dioxide Mediated High Efficiency Photodegradation of Fluazifop-p-Butyl.International journal of environmental research and public health · 2019Article
- Quizalofop-p-Ethyl Induces Adipogenesis in 3T3-L1 Adipocytes.Toxicological sciences : an official journal of the Society of Toxicology · 2019Article
- Industrial, Biocide, and Cosmetic Chemical Inducers of Cholestasis.Chemical research in toxicology · 2019Article
- Recent insights into the microbial catabolism of aryloxyphenoxy-propionate herbicides: microbial resources, metabolic pathways and catabolic enzymes.World journal of microbiology & biotechnology · 2018Review
- Comparison of transcriptome responses to glyphosate, isoxaflutole, quizalofop-p-ethyl and mesotrione in the HepaRG cell line.Toxicology reports · 2018Article
- Purification and properties of a novel quizalofop-p-ethyl-hydrolyzing esterase involved in quizalofop-p-ethyl degradation by Pseudomonas sp. J-2.Microbial cell factories · 2017Article
- Hepatotoxicity, Nephrotoxicity and Oxidative Stress in Rat Testis Following Exposure to Haloxyfop-Toxics · 2015Article
- Practical guidelines for diagnosis and early management of drug-induced liver injury.World journal of gastroenterology · 2008Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextQuizalofop-p-ethyl is an often applied, slightly toxic herbicide for which no severe toxicity has been reported in humans. CASE PRESENTATION: We present the case of a farmer exposed to quizalofop-p-ethyl who presented with obstructive cholestasis. A complete workup disclosed no other cause of liver pathology, but liver biopsy established drug-induced hepatotoxicity. The patient was treated with ursodeoxycholic acid and prednisolone, and was recovered fully 70 days after his exposure to the herbicide. The patient was followed for the next 9 months.
conclusionQuizalofop-p-ethyl can induce a mixed cholestatic/hepatocellular liver injury. We discuss possible mechanisms implicated in liver injury after exposure to quizalofop-p-ethyl. RELEVANCE TO CLINICAL OR PROFESSIONAL PRACTICE: In patients presenting with mixed cholestatic/ hepatocellular liver injury, occupational exposure to quizalofop-p-ethyl in the course of agricultural use should be investigated.
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