SynthesisEnvironmental health perspectives2007
Developing asthma in childhood from exposure to secondhand tobacco smoke: insights from a meta-regression.
Synthesis in Environmental health perspectives, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
42 citing papers in PubMed, 2 syntheses or guidelines pooled it, 124 citations in OpenAlex.
- Association between childhood asthma and history of assisted reproduction techniques: a systematic review and meta-analysis.European journal of pediatrics · 2021Pooled it
- A systematic review of associations between environmental exposures and development of asthma in children aged up to 9 years.BMJ open · 2014Pooled it
- Cotinine versus questionnaire: early-life environmental tobacco smoke exposure and incident asthma.BMC pediatrics · 2012Trial
- Impact of Environmental Exposure on Infant Sleep : The Exposome Approach.Journal of sleep research · 2026Review
- Unraveling the impact of indoor air pollution on respiratory health in people living with HIV within a high-prevalence HIV cohort.BMC pulmonary medicine · 2025Article
- The Role of Environmental Exposures in Pediatric Asthma Pathogenesis: A Contemporary Narrative Review.Children (Basel, Switzerland) · 2025Review
- Early childhood lower-airway symptoms and airway hyperresponsiveness linked to school-age small-airway dysfunction.The journal of allergy and clinical immunology. Global · 2025Article
- The Role of the Microbiota in the Pathogenesis and Treatment of Atopic Dermatitis-A Literature Review.International journal of molecular sciences · 2024Review
- Environmental justice and allergic disease: A Work Group Report of the AAAAI Environmental Exposure and Respiratory Health Committee and the Diversity, Equity and Inclusion Committee.The Journal of allergy and clinical immunology · 2023Article
- The effect of 3-year parental smoking on asthma status of their children.The clinical respiratory journal · 2022Article
- Time-Specific Factors Influencing the Development of Asthma in Children.Biomedicines · 2022Review
- Wheezing-Related Relevant Factors and the Role of Viral Bronchiolitis.Frontiers in allergy · 2021Review
- Indoor Air Pollution and Respiratory Health.Clinics in chest medicine · 2020Review
- Factors Associated with the Development of Childhood Asthma in Japan: A Nationwide Longitudinal Study.Maternal and child health journal · 2020Article
- Environmental exposures and mechanisms in allergy and asthma development.The Journal of clinical investigation · 2019Review
- Air Pollution and Climate Change Effects on Allergies in the Anthropocene: Abundance, Interaction, and Modification of Allergens and Adjuvants.Environmental science & technology · 2017Article
- Prevalence and Risk Factors of Asthma, Rhinitis, and Eczema and Their Multimorbidity among Young Adults in Kuwait: A Cross-Sectional Study.BioMed research international · 2017Article
- Postnatal environmental tobacco smoke exposure is associated with objective markers of atopy in preschool-aged children.Evidence-based medicine · 2015Article
- Asthma.Nature reviews. Disease primers · 2015Review
- Observational
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveStudies have identified associations between household secondhand tobacco smoke (SHS) exposure and induction of childhood asthma. However, the true nature and strength of this association remains confounded in many studies, producing inconsistent evidence. To look for sources of potential bias and try to uncover consistent patterns of relative risk estimates (RRs), we conducted a meta-analysis of studies published between 1970 and 2005. DATA SOURCES: Through an extensive literature search, we identified 38 epidemiologic studies of SHS exposure and the development of childhood asthma (that also controlled for atopy history) from 300 potentially relevant articles. DATA SYNTHESIS: We observed substantial heterogeneity within initial summary RRs of 1.48 [95% confidence interval (CI), 1.32-1.65], 1.25 (1.21-1.30), and 1.21 (1.08-1.36), for ever, current, and incident asthma, respectively. Lack of control for type of atopy history (familial or child) and child's own smoking status within studies and age category altered summary RRs in separate meta-regressions. After adjusting for these confounding characteristics, consistent patterns of association emerged between SHS exposure and childhood asthma induction. Our summary RR of 1.33 (95% CI, 1.14-1.56) from studies of incident asthma among older children (6-18 years of age) is 1.27 times the estimate from studies of younger children and higher than estimates reported in earlier meta-analyses.
conclusionsThis new finding indicates that exposure duration may be a more important factor in the induction of asthma than previously understood, and suggests that SHS could be a more fundamental and widespread cause of childhood asthma than some previous meta-analyses have indicated.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.