Evidence map›Paper›PMID 17938638›Full record

SynthesisMolecular psychiatry2008

Meta-analyses of genetic studies on major depressive disorder.

S López-León, A C J W Janssens, A M González-Zuloeta Ladd, J Del-Favero, S J Claes, B A Oostra, C M van Duijn

Registry-linked trialAbstract readMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Molecular psychiatry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05563324 (Genetics of Self-injurious Behaviour), which is not on this map. Cited by 161 papers, 19 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
161citing papers in PubMed, 19 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05563324 completednot on this mapstarted 2014, after this paper: background citation

Genetics of Self-injurious Behaviour

TypeobservationalSponsorUniversity Medical Centre MariborRan2014 to 2018Enrolled234ConditionsSelf Injurious Behavior Without Suicidal Intent, Self-Injurious BehaviorArmsDNA extraction and genotyping of candidate genetic polymorphisms, self-assessment questionnaires
3 · Its place in the literature

Who cites it

161 citing papers in PubMed, 19 syntheses or guidelines pooled it.

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  7. Meta-Analysis of the COMT Val158Met Polymorphism in Major Depressive Disorder: Effect of Ethnicity.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2016
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  11. No association of genetic variants in BDNF with major depression: a meta- and gene-based analysis.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2013
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101 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

S López-LeónGenetic-Epidemiology Unit, Department of Epidemiology and Biostatistics, Erasmus University Medical Center, Rotterdam, The Netherlands.
A C J W Janssens
A M González-Zuloeta Ladd
J Del-Favero
S J Claes
B A Oostra
C M van Duijn

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The genetic basis of major depressive disorder (MDD) has been investigated extensively, but the identification of MDD genes has been hampered by conflicting results from underpowered studies. We review all MDD case-control genetic association studies published before June 2007 and perform meta-analyses for polymorphisms that had been investigated in at least three studies. The study selection and data extraction were performed in duplicate by two independent investigators. The 183 papers that met our criteria studied 393 polymorphisms in 102 genes. Twenty-two polymorphisms (6%) were investigated in at least three studies. Seven polymorphisms had been evaluated in previous meta-analyses, 5 of these had new data available. Hence, we performed meta-analyses for 20 polymorphisms in 18 genes. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated. Statistically significant associations were found for the APOE varepsilon2 (OR, 0.51), GNB3 825T (OR, 1.38), MTHFR 677T (OR, 1.20), SLC6A4 44 bp Ins/Del S (OR, 1.11) alleles and the SLC6A3 40 bpVNTR 9/10 genotype (OR, 2.06). To date, there is statistically significant evidence for six MDD susceptibility genes (APOE, DRD4, GNB3, MTHFR, SLC6A3 and SLC6A4).

Indexed as

Polymorphism, GeneticDopamine Plasma Membrane Transport ProteinsGenetic Predisposition to DiseaseHumansMajor Depressive DisorderMembrane GlycoproteinsMembrane Transport ProteinsPolymorphism, Single NucleotideSequence DeletionTaurine TransportersDopamine Plasma Membrane Transport ProteinsMembrane GlycoproteinsMembrane Transport ProteinsSLC6A3 protein, humanTaurine Transporters

Identifiers

PMID17938638

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.