ArticleMolecular psychiatry2008
A comparison between screened NIMH and clinically interviewed control samples on neuroticism and extraversion.
Article in Molecular psychiatry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 19 citations in OpenAlex.
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- Genotyping serotonin transporter polymorphisms 5-HTTLPR and rs25531 in European- and African-American subjects from the National Institute of Mental Health's Collaborative Center for Genomic Studies.Translational psychiatry · 2013Article
- Refinement and discovery of new hotspots of copy-number variation associated with autism spectrum disorder.American journal of human genetics · 2013Article
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- Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations.Nature · 2012Article
- Genomic architecture of aggression: rare copy number variants in intermittent explosive disorder.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2011Article
- Relative burden of large CNVs on a range of neurodevelopmental phenotypes.PLoS genetics · 2011Article
- Translational epidemiology in psychiatry: linking population to clinical and basic sciences.Archives of general psychiatry · 2011Review
- Reduced transcript expression of genes affected by inherited and de novo CNVs in autism.European journal of human genetics : EJHG · 2011Article
- Effects of sexual orientation and gender on perceived need for treatment by persons with and without mental disorders.Psychiatric services (Washington, D.C.) · 2011Article
- The Internet-based MGS2 control sample: self report of mental illness.The American journal of psychiatry · 2010Article
- Association of a polyadenylation polymorphism in the serotonin transporter and panic disorder.Biological psychiatry · 2010Article
- Panic disorder is associated with the serotonin transporter gene (SLC6A4) but not the promoter region (5-HTTLPR).Molecular psychiatry · 2010Article
- Influence of gender, sexual orientation, and need on treatment utilization for substance use and mental disorders: findings from the California Quality of Life Survey.BMC psychiatry · 2009Article
- Burden of psychiatric morbidity among lesbian, gay, and bisexual individuals in the California Quality of Life Survey.Journal of abnormal psychology · 2009Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The National Institute of Mental Health (NIMH) has supported the collection of DNA samples on over 4000 subjects for use primarily as controls in psychiatric genetic studies. These subjects, though screened online, were not directly interviewed or assessed on family history. We compared this sample to one that was directly interviewed using structured diagnostic assessments on comparable measures of neuroticism and extraversion. The screened sample completed an online self-report based on the Composite International Diagnostic Instrument Short-Form (CIDI-SF). The interviewed sample was assessed by clinically trained personnel using the Schedule for Affective Disorders and Schizophrenia (SADS-LA-IV) and Family History Screen; final diagnoses were made blind to trait scores by a clinician using the best-estimate procedure. Neuroticism and extraversion were assessed on the NEO five-factor inventory (NEO-FFI) and the revised Eysenck Personality Questionnaire short form (EPQ-R). We found that subjects in the NIMH-screened sample who did not report any psychiatric symptoms on the self-report were indistinguishable from interviewed diagnosis free and family history negative controls on neuroticism and extraversion. Subjects in the screened sample who screened positive for anxiety disorders, however, deviated significantly on these measures both from the screened subjects with no self-reported symptoms, as well as from subjects in the interviewed sample diagnosed with comparable disorders. These findings suggest that control groups generated from the NIMH sample should ideally be restricted to subjects free of any self-reported symptoms, regardless of the disorder being addressed, in order to maximize their reflection of diagnosis-free populations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.