ArticleDementia and geriatric cognitive disorders2007
The heritability of abstract reasoning in Caribbean Latinos with familial Alzheimer disease.
Article in Dementia and geriatric cognitive disorders, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 11 citations in OpenAlex.
- Association between theSchizophrenia research. Cognition · 2024Article
- Genetics of Alzheimer's disease in Caribbean Hispanic and African American populations.Biological psychiatry · 2014Review
- No observable relationship between the 12 genes of nervous system and reasoning skill in a young Chinese Han population.Cellular and molecular neurobiology · 2011Article
- Alzheimer disease and cognitive reserve: variation of education effect with carbon 11-labeled Pittsburgh Compound B uptake.Archives of neurology · 2008Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundAlzheimer disease (AD) is under substantial genetic influence. To better understand the genetic influence on component phenotypes of AD, we estimated the heritability (h(2)) of abstract reasoning and examined its relation with apolipoprotein epsilon 4 (APOE-epsilon 4).
methodsWe studied abstract reasoning in 1,116 individuals from 210 Caribbean Hispanic families with late onset AD, using the similarities subtest scores from the Wechsler Adult Intelligence Scale. We computed h(2), then performed analysis of variance to examine the effect of APOE-epsilon 4.
resultsAbstract reasoning was highly heritable (h(2)(unadjusted) = 79.9%). After adjusting for covariates, the h(2) was reduced to 32.6%, with education accounting for 40.8% of the variance. The APOE-epsilon 4 allele had no effect.
conclusionAbstract reasoning was strongly influenced by genetic factors and education. Genes other than APOE contribute to the inheritance of abstract reasoning ability.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.