ArticleBlood2008
Critical role for Rsk2 in T-lymphocyte activation.
Article in Blood, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 37 citations in OpenAlex.
- AKAP6β-a conductor in the orchestra of pathological cardiomyocyte gene transcription.Molecular pharmacology · 2026Review
- Therapeutic targeting of p90 ribosomal S6 kinase.Frontiers in cell and developmental biology · 2023Review
- Depression, dementia and immune dysregulation.Brain : a journal of neurology · 2021Article
- Extracellular signal-regulated kinase (ERK) pathway control of CD8+ T cell differentiation.The Biochemical journal · 2021Article
- Aberrant expression of RSK1 characterizes high-grade gliomas with immune infiltration.Molecular oncology · 2020Article
- Kaempferol targeting on the fibroblast growth factor receptor 3-ribosomal S6 kinase 2 signaling axis prevents the development of rheumatoid arthritis.Cell death & disease · 2018Article
- RSK2 phosphorylates T-bet to attenuate colon cancer metastasis and growth.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- RSK2 activity mediates glioblastoma invasiveness and is a potential target for new therapeutics.Oncotarget · 2016Article
- RSK3 is required for concentric myocyte hypertrophy in an activated Raf1 model for Noonan syndrome.Journal of molecular and cellular cardiology · 2016Article
- The PDK1-Rsk Signaling Pathway Controls Langerhans Cell Proliferation and Patterning.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Regulation of NHE3 by lysophosphatidic acid is mediated by phosphorylation of NHE3 by RSK2.American journal of physiology. Cell physiology · 2015Article
- RSK3: A regulator of pathological cardiac remodeling.IUBMB life · 2015Review
- RNA interference screening identifies lenalidomide sensitizers in multiple myeloma, including RSK2.Blood · 2015Article
- Computational and Biochemical Discovery of RSK2 as a Novel Target for Epigallocatechin Gallate (EGCG).PloS one · 2015Article
- DGCR14 induces Il17a gene expression through the RORγ/BAZ1B/RSKS2 complex.Molecular and cellular biology · 2015Article
- Serine-threonine kinases in TCR signaling.Nature immunology · 2014Review
- Kaposi's sarcoma-associated herpesvirus ORF45 mediates transcriptional activation of the HIV-1 long terminal repeat via RSK2.Journal of virology · 2014Article
- Identification of germ cell-specific genes in mammalian meiotic prophase.BMC bioinformatics · 2013Article
- The use of growth factors to modulate the activities of antigen-specific CD8+ T cells in vitro.Journal of medicine and life · 2011Article
- p90RSK2 is essential for FLT3-ITD- but dispensable for BCR-ABL-induced myeloid leukemia.Blood · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
During T-cell activation, a number of cytokine-activated signaling cascades, including the Jak-STAT, phosphoinositol 3-kinase (PI 3-kinase), and mitogen-activated protein kinase (MAPK) pathways, play important roles in modulating the expression of target genes and mediating a cellular response. We now report that interleukin 2 (IL-2) and IL-15, but not IL-7, rapidly activate the p90 ribosomal S6 kinases, Rsk1 and Rsk2, in human T lymphocytes. Surprisingly, mouse spleen T cells transduced with either the wild-type or a dominant-negative (DN) Rsk2-expressing retrovirus could not be recovered, in contrast to the normal survival of T cells transduced with retroviruses expressing wild-type or DN mutants of Rsk1 or Rsk3. Examination of Rsk2 knockout (KO) mice revealed normal T-cell development, but these T cells had delayed cell-cycle progression and lower production of IL-2 in response to anti-CD3 and anti-CD28 stimulation in vitro. Moreover, Rsk2 KO mice had defective homeostatic T-cell expansion following sublethal irradiation in vivo, which is known to involve T-cell receptor (TCR), IL-2, and/or IL-15 signals, each of which we demonstrate can rapidly and potently activate Rsk2 in mouse T cells. These results indicate an essential nonredundant role of Rsk2 in T-cell activation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.