ArticleThe Journal of experimental medicine2007
A constant affinity threshold for T cell tolerance.
Article in The Journal of experimental medicine, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed.
- Identification of Rare Antigen-Specific T Cells from Mouse Lungs with Peptide:Major Histocompatibility Complex Tetramers.Journal of visualized experiments : JoVE · 2024Article
- Mathematical models of TCR initial triggering.Frontiers in immunology · 2024Review
- Challenges and solutions for therapeutic TCR-based agents.Immunological reviews · 2023Review
- The thymoproteasome in shaping the CD8Current opinion in immunology · 2023Review
- Discrete LAT condensates encode antigen information from single pMHC:TCR binding events.Nature communications · 2022Article
- Signal strength controls the rate of polarization within CTLs during killing.The Journal of cell biology · 2021Article
- T-cell receptor affinity in the age of cancer immunotherapy.Molecular carcinogenesis · 2020Review
- Dynamics of the Coreceptor-LCK Interactions during T Cell Development Shape the Self-Reactivity of Peripheral CD4 and CD8 T Cells.Cell reports · 2020Article
- Mature Dendritic Cells May Promote High-Avidity Tuning of Vaccine T Cell Responses.Frontiers in immunology · 2020Article
- TCR Affinity for In Vivo Peptide-Induced Thymic Positive Selection Fine-Tunes TCR Responsiveness of Peripheral CD8Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- Mapping the stochastic sequence of individual ligand-receptor binding events to cellular activation: T cells act on the rare events.Science signaling · 2019Article
- Avidity characterization of genetically engineered T-cells with novel and established approaches.BMC immunology · 2016Article
- T-cell reprogramming through targeted CD4-coreceptor and T-cell receptor expression on maturing thymocytes by latent Circoviridae family member porcine circovirus type 2 cell infections in the thymus.Emerging microbes & infections · 2015Article
- A THEMIS:SHP1 complex promotes T-cell survival.The EMBO journal · 2015Article
- A biased competition theory of cytotoxic T lymphocyte interaction with tumor nodules.PloS one · 2015Article
- Optimal T-cell receptor affinity for inducing autoimmunity.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Immunology: Tolerance lies in the timing.Nature · 2014Article
- Article
- Quorum sensing allows T cells to discriminate between self and nonself.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Subtle changes in TCRα CDR1 profoundly increase the sensitivity of CD4 T cells.Molecular immunology · 2013Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
T cell tolerance depends on the T cell receptor's affinity for peptide/major histocompatibility complex (MHC) ligand; this critical parameter determines whether a thymocyte will be included (positive selection) or excluded (negative selection) from the T cell repertoire. A quantitative analysis of ligand binding was performed using an experimental system permitting receptor-coreceptor interactions on live cells under physiological conditions. Using three transgenic mouse strains expressing distinct class I MHC-restricted T cell receptors, we determined the affinity that defines the threshold for negative selection. The affinity threshold for self-tolerance appears to be a constant for cytotoxic T lymphocytes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.