ArticleInfection and immunity2008
Fibrotic response as a distinguishing feature of resistance and susceptibility to pulmonary infection with Mycobacterium tuberculosis in mice.
Article in Infection and immunity, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed.
- Human pluripotent stem cell-derived skin organoids enabled pathophysiological model of Mycobacterium tuberculosis infection.Nature communications · 2025Article
- Immunological roads diverged: mapping tuberculosis outcomes in mice.Trends in microbiology · 2025Review
- The Utilization of Plant-Material-Loaded Vesicular Drug Delivery Systems in the Management of Pulmonary Diseases.Current issues in molecular biology · 2023Review
- Genome-wide screen identifies host loci that modulate Mycobacterium tuberculosis fitness in immunodivergent mice.G3 (Bethesda, Md.) · 2023Article
- Genome-wide screen identifies host loci that modulatebioRxiv : the preprint server for biology · 2023Article
- SPARC coordinates extracellular matrix remodeling and efficient recruitment to and migration of antigen-specific T cells in the brain following infection.Scientific reports · 2021Article
- A bioinformatics analysis to identify novel biomarkers for prognosis of pulmonary tuberculosis.BMC pulmonary medicine · 2020Article
- Immune correlates of tuberculosis disease and risk translate across species.Science translational medicine · 2020Article
- A Compartmentalized Profibrotic Immune Response Characterizes Pericardial Tuberculosis, Irrespective of HIV-1 Infection.American journal of respiratory and critical care medicine · 2015Article
- Molecular network of important genes for systemic sclerosis-related progressive lung fibrosis.BMC research notes · 2015Article
- Vaccination with an Attenuated Ferritin Mutant Protects Mice against Virulent Mycobacterium tuberculosis.Journal of immunology research · 2015Article
- The Saguenay-Lac-Saint-Jean asthma familial collection: the genetics of asthma in a young founder population.Genes and immunity · 2014Article
- Immunohistological characterization of spinal TB granulomas from HIV-negative and -positive patients.Tuberculosis (Edinburgh, Scotland) · 2013Article
- Article
- Early control of Mycobacterium tuberculosis infection requires il12rb1 expression by rag1-dependent lineages.Infection and immunity · 2012Article
- Blockade of IL-10 signaling during bacillus Calmette-Guérin vaccination enhances and sustains Th1, Th17, and innate lymphoid IFN-γ and IL-17 responses and increases protection to Mycobacterium tuberculosis infection.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Identification of a novel cerebral malaria susceptibility locus (Berr5) on mouse chromosome 19.Genes and immunity · 2010Article
- Restriction of Legionella pneumophila replication in macrophages requires concerted action of the transcriptional regulators Irf1 and Irf8 and nod-like receptors Naip5 and Nlrc4.Infection and immunity · 2009Article
- Genetic and functional characterization of the mouse Trl3 locus in defense against tuberculosis.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- Disseminated and rapidly fatal tuberculosis in mice bearing a defective allele at IFN regulatory factor 8.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The differential susceptibility of inbred mouse strains DBA/2J (susceptible) and C57BL/6J (resistant) to pulmonary tuberculosis following aerosol infection is under complex genetic control. In this report, transcriptional profiling with RNAs from Mycobacterium tuberculosis-infected lungs was used to investigate the physiological response, cell type, and biochemical pathways underlying differential susceptibility to infection. Statistical analysis of cDNA-based microarrays revealed that 1,097 transcripts showed statistically significant changes in abundance (changes of > or = 1.5-fold) in at least one of four experimental group comparisons (C57BL/6J [day 0] versus DBA/2J [day 0] mice, C57BL/6J [day 90] versus DBA/2J [day 90] mice, C57BL/6J [day 90] versus C57BL/6J [day 0] mice, or DBA/2J [day 90] versus DBA/2J [day 0] mice). A group of genes showing very high degrees of significance (changes of > or = 2.0-fold) displayed enrichment for transcripts associated with tissue remodeling and the fibrotic response. The differential expression of fibrotic response genes (Sparc, Col1a1, Col1a2, Col4a1, and Col4a2) in the infected lungs of the two mouse strains was validated by another microarray platform (Affymetrix oligonucleotide chips) and by reverse transcription-PCR. Furthermore, the differential expression of additional genes known to be associated with fibrosis (Mmp2, Timp1, and Arg1) was also validated by these approaches. Overall, these results identify the differential fibrotic response as a pathological basis for the high susceptibility of DBA/2J mice to pulmonary tuberculosis.
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Registered trials
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