ArticleMolecular and cellular biology2007
CHD8 associates with human Staf and contributes to efficient U6 RNA polymerase III transcription.
Article in Molecular and cellular biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 71 citations in OpenAlex.
- Molecular interactions of Chd8 in mouse brain highlights a role in chromatin-associated RNA processing.bioRxiv : the preprint server for biology · 2025Article
- Bromodomain-containing proteins in the unicellular eukaryoteZoological research · 2025Review
- A CHD8-TRRAP axis facilitates MYC and E2F target gene regulation in human neural stem cells.iScience · 2025Article
- Structural insights into distinct mechanisms of RNA polymerase II and III recruitment to snRNA promoters.Nature communications · 2025Article
- The choreography of chromatin in RNA polymerase III regulation.Biochemical Society transactions · 2024Review
- The autism risk factor CHD8 is a chromatin activator in human neurons and functionally dependent on the ERK-MAPK pathway effector ELK1.Scientific reports · 2022Article
- Exploring the role of RALYL in Alzheimer's disease reserve by network-based approaches.Alzheimer's research & therapy · 2020Article
- De Novo Damaging DNA Coding Mutations Are Associated With Obsessive-Compulsive Disorder and Overlap With Tourette's Disorder and Autism.Biological psychiatry · 2020Article
- 7C: Computational Chromosome Conformation Capture by Correlation of ChIP-seq at CTCF motifs.BMC genomics · 2019Article
- Autism-linked CHD gene expression patterns during development predict multi-organ disease phenotypes.Journal of anatomy · 2018Article
- RNA Polymerase II Activity of Type 3 Pol III Promoters.Molecular therapy. Nucleic acids · 2018Article
- Altered Neocortical Gene Expression, Brain Overgrowth and Functional Over-Connectivity in Chd8 Haploinsufficient Mice.Cerebral cortex (New York, N.Y. : 1991) · 2018Article
- The life of U6 small nuclear RNA, from cradle to grave.RNA (New York, N.Y.) · 2018Review
- Common CHD8 Genomic Targets Contrast With Model-Specific Transcriptional Impacts ofFrontiers in molecular neuroscience · 2018Article
- ZNF143 protein is an important regulator of the myeloid transcription factor C/EBPα.The Journal of biological chemistry · 2017Article
- Computational characterization of chromatin domain boundary-associated genomic elements.Nucleic acids research · 2017Article
- Regulation of expression of human RNA polymerase II-transcribed snRNA genes.Open biology · 2017Review
- Human RNase P ribonucleoprotein is required for formation of initiation complexes of RNA polymerase III.Nucleic acids research · 2015Article
- The B-WICH chromatin-remodelling complex regulates RNA polymerase III transcription by promoting Max-dependent c-Myc binding.Nucleic acids research · 2015Article
- The chromatin Remodeler CHD8 is required for activation of progesterone receptor-dependent enhancers.PLoS genetics · 2015Article
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
Chromatin remodeling and histone modification are essential for eukaryotic transcription regulation, but little is known about chromatin-modifying activities acting on RNA polymerase III (Pol III)-transcribed genes. The human U6 small nuclear RNA promoter, located 5' of the transcription start site, consists of a core region directing basal transcription and an activating region that recruits the transcription factors Oct-1 and Staf (ZNF143). Oct-1 activates transcription in part by helping recruit core binding factors, but nothing is known about the mechanisms of transcription activation by Staf. We show that Staf activates U6 transcription from a preassembled chromatin template in vitro and associates with several proteins linked to chromatin modification, among them chromodomain-helicase-DNA binding protein 8 (CHD8). CHD8 binds to histone H3 di- and trimethylated on lysine 4. It resides on the human U6 promoter as well as the mRNA IRF3 promoter in vivo and contributes to efficient transcription from both these promoters. Thus, Pol III transcription from type 3 promoters uses some of the same factors used for chromatin remodeling at Pol II promoters.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.