ArticleAlcohol (Fayetteville, N.Y.)2007
Differential effects of ethanol and midazolam upon the devaluation of an aversive memory in infant rats.
Article in Alcohol (Fayetteville, N.Y.), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 33 citations in OpenAlex.
- Moderate ethanol exposure during early ontogeny of the rat alters respiratory plasticity, ultrasonic distress vocalizations, increases brain catalase activity, and acetaldehyde-mediated ethanol intake.Frontiers in behavioral neuroscience · 2022Article
- Fetal Alcohol Programming of Subsequent Alcohol Affinity: A Review Based on Preclinical, Clinical and Epidemiological Studies.Frontiers in behavioral neuroscience · 2020Review
- Adult-onset hypothyroidism increases ethanol consumption.Psychopharmacology · 2019Article
- Brain Acetaldehyde Exposure Impacts upon Neonatal Respiratory Plasticity and Ethanol-Related Learning in Rodents.Frontiers in behavioral neuroscience · 2017Article
- Age-related effects of chronic restraint stress on ethanol drinking, ethanol-induced sedation, and on basal and stress-induced anxiety response.Alcohol (Fayetteville, N.Y.) · 2016Article
- Extinction learning is slower, weaker and less context specific after alcohol.Neurobiology of learning and memory · 2015Article
- New evidence of ethanol's anxiolytic properties in the infant rat.Alcohol (Fayetteville, N.Y.) · 2014Article
- μ-Opioid blockade reduces ethanol effects on intake and behavior of the infant rat during short-term but not long-term social isolation.Pharmacology, biochemistry, and behavior · 2013Article
- Prenatal ethanol exposure increases ethanol intake and reduces c-Fos expression in infralimbic cortex of adolescent rats.Pharmacology, biochemistry, and behavior · 2013Article
- Early role of the κ opioid receptor in ethanol-induced reinforcement.Physiology & behavior · 2012Article
- The role of social isolation in ethanol effects on the preweanling rat.Behavioural brain research · 2012Article
- Early maternal separation affects ethanol-induced conditioning in a nor-BNI insensitive manner, but does not alter ethanol-induced locomotor activity.Pharmacology, biochemistry, and behavior · 2012Article
- Fetal exposure to moderate ethanol doses: heightened operant responsiveness elicited by ethanol-related reinforcers.Alcoholism, clinical and experimental research · 2009Article
- Opioid antagonists block the acquisition of ethanol-mediated conditioned tactile preference in infant rats.Alcohol (Fayetteville, N.Y.) · 2009Article
- Assessing appetitive, aversive, and negative ethanol-mediated reinforcement through an immature rat model.Neuroscience and biobehavioral reviews · 2009Review
- Novelty modulates the stimulating motor effects of ethanol in preweanling rats.Pharmacology, biochemistry, and behavior · 2009Article
- Ethanol-mediated operant learning in the infant rat leads to increased ethanol intake during adolescence.Pharmacology, biochemistry, and behavior · 2008Article
- Acute sensitivity and acute tolerance to ethanol in preweanling rats with or without prenatal experience with the drug.Pharmacology, biochemistry, and behavior · 2008Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
In infant rats, low doses of ethanol (EtOH) have been found to attenuate the aversive representation of an unconditioned stimulus (US) as assessed through a revaluation paradigm. This may be explained by early anxiolytic properties of EtOH. The present set of experiments was aimed at analyzing possible mechanisms of these putative antianxiety effects of EtOH. In the first experiment, EtOH's effects upon the expression of citric acid-induced distress calls were compared with varying doses of midazolam (MDZ), a fast-acting gamma-aminobutyric acid type A (GABA(A)) agonist. Similar calming effects of 0.5 g/kg EtOH and 0.09 mg/kg MDZ were observed. Both drugs were then assessed in their capability to alter the expression of a conditioned aversion by devaluing the US. Aversive conditioning was conducted on postnatal day 14 (PD14) by pairing a lemon odor (conditioned stimulus, CS) with intraoral stimulation of citric acid (US). Control animals experienced both stimuli in an explicitly unrelated fashion. On PD15, pups were briefly exposed to the citric acid solution under the effects of 0.5 g/kg EtOH, 0.09 mg/kg MDZ, or the respective vehicle for each drug. Pups were then tested in a two-way odor preference test (lemon vs. cineole). Both vehicle- and MDZ-treated animals spent significantly less time near the lemon CS, thus expressing a citric acid-mediated odor aversion. This conditioned response was completely inhibited in pups that received 0.5 g/kg EtOH. Locomotor patterns at test were not affected by either EtOH or MDZ administration. A higher dose of MDZ (0.18 mg/kg, intraperitoneal) was also ineffective in attenuating the aversive memory. In summary, EtOH's devaluating capabilities are not shared by MDZ, indicating that these effects of EtOH may not be GABA mediated. Appetitive motivational properties of EtOH or non-GABA(A)-mediated antianxiety effects [i.e., N-methyl-D-aspartic acid (NMDA) related] could underlie this devaluation effect of EtOH.
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