ArticlePharmacology, biochemistry, and behavior2008
A novel rat strain with enhanced sensitivity to the effects of dopamine agonists on startle gating.
Article in Pharmacology, biochemistry, and behavior, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 22 citations in OpenAlex.
- Sprague Dawley rats from different vendors vary in the modulation of prepulse inhibition of startle (PPI) by dopamine, acetylcholine, and glutamate drugs.Psychopharmacology · 2023Article
- What makes you tic? Translational approaches to study the role of stress and contextual triggers in Tourette syndrome.Neuroscience and biobehavioral reviews · 2017Review
- Thyroxine administration prevents matrilineal intergenerational consequences of in utero ethanol exposure in rats.Hormones and behavior · 2016Article
- Intergenerational and parent of origin effects of maternal calorie restriction on Igf2 expression in the adult rat hippocampus.Psychoneuroendocrinology · 2014Article
- Intergenerational effects of prenatal ethanol on glucose tolerance and insulin response.Physiological genomics · 2014Article
- Forebrain gene expression predicts deficits in sensorimotor gating after isolation rearing in male rats.Behavioural brain research · 2013Article
- The effects of oxytocin and its analog, carbetocin, on genetic deficits in sensorimotor gating.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2012Article
- Disparate effects of pramipexole on locomotor activity and sensorimotor gating in Sprague-Dawley rats.Pharmacology, biochemistry, and behavior · 2011Article
- Clozapine and PD149163 elevate prepulse inhibition in Brown Norway rats.Behavioral neuroscience · 2011Article
- Parametric approaches towards understanding the effects of the preferential D3 receptor agonist pramipexole on prepulse inhibition in rats.Pharmacology, biochemistry, and behavior · 2010Article
- Article
- Sensory and sensorimotor gating-disruptive effects of apomorphine in Sprague Dawley and Long Evans rats.Behavioural brain research · 2010Article
- Interaction between the effects of corticotropin-releasing factor and prepulse parameters on prepulse inhibition in two inbred rat strains and the F1 generation of a cross between them.Behavioural brain research · 2009Article
- Realistic expectations of prepulse inhibition in translational models for schizophrenia research.Psychopharmacology · 2008Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundCompared to outbred Sprague Dawley (SD) rats, inbred Brown Norway (BN) rats exhibit less prepulse inhibition of startle (PPI) at long prepulse intervals, and more PPI at short intervals. Sensitivity to dopaminergic drug effects on PPI differs substantially across strains, and is heritable within SD and other outbred strains. To further understand the heritability of PPI and its sensitivity to dopamine agonists, we assessed PPI and apomorphine sensitivity in SD, BN and F1 (SD x BN) rats.
methodsPPI was measured in BN, SD and F1 rats under a variety of stimulus conditions, and after treatment with apomorphine.
resultsFindings confirmed significantly more PPI in BN compared to SD rats at short prepulse intervals, and significantly more PPI in SD compared to BN rats at long intervals. F1s were "supersensitive" to both the PPI-disruptive effects of apomorphine at longer intervals, and the PPI-enhancing effects of apomorphine at shorter intervals, compared to either parental strain.
conclusionDifferences in sensorimotor gating between SD and BN rats are robust, time-locked and consistent across studies. Unlike patterns in other strains, heritability of PPI apomorphine sensitivity phenotypes in SD x BN F1s cannot be easily explained by simple additive effects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.