ArticleDigestive diseases and sciences2008
Effect of a gluten-free diet on the risk of enteropathy-associated T-cell lymphoma in celiac disease.
Article in Digestive diseases and sciences, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05186038 (Scrutiny Based in a Novel Test to Help the Early Detection of Celiac Disease.), which is not on this map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Scrutiny Based in a Novel Test to Help the Early Detection of Celiac Disease.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 84 citations in OpenAlex.
- Guideline
- Review
- Malignancies in Celiac Disease-A Hidden Threat with Diagnostic Pitfalls.Biomedicines · 2025Review
- The link between gluten intake and the risk of cancers.Gastroenterology and hepatology from bed to bench · 2024Review
- Salivary gland involvement and oral health in patients with coeliac disease.European journal of oral sciences · 2022Article
- Review
- Review
- Association between intestinal neoplasms and celiac disease: A review.World journal of gastrointestinal oncology · 2021Review
- Small Bowel Carcinomas Associated with Immune-Mediated Intestinal Disorders: The Current Knowledge.Cancers · 2018Review
- Pathogenesis of Enteropathy-Associated T Cell Lymphoma.Current hematologic malignancy reports · 2018Review
- Updates of Peripheral T Cell Lymphomas Based on the 2017 WHO Classification.Current hematologic malignancy reports · 2018Review
- Review
- Overview of Celiac Disease in Russia: Regional Data and Estimated Prevalence.Journal of immunology research · 2017Review
- Enteropathy-Associated T-Cell Lymphoma.Current hematologic malignancy reports · 2016Review
- Dietary compliance in Iranian children and adolescents with celiac disease.Journal of multidisciplinary healthcare · 2016Article
- Elderly Onset Celiac Disease: A Narrative Review.Clinical medicine insights. Gastroenterology · 2016Review
- Screening for celiac disease in the general population and in high-risk groups.United European gastroenterology journal · 2015Review
- Enteropathy-associated T cell lymphoma as a complication of silent celiac disease.Hematology reports · 2014Article
- Geographic trends and risk of gastrointestinal cancer among patients with celiac disease in Europe and Asian-Pacific region.Gastroenterology and hepatology from bed to bench · 2013Review
- Untreated celiac disease in a patient with dermatitis herpetiformis leading to a small bowel carcinoma.Case reports in gastroenterology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Patients with celiac disease have an increased rate of enteropathy-associated T-cell lymphoma, but conflicting data are available about the protective role of a gluten-free diet with regard to the development of this malignancy. We followed 1,757 celiac patients for a total period of 31,801 person-years, collecting data about the frequency of gluten intake and the incidence of the enteropathy-associated T-cell lymphoma. Out of the nine celiac patients who developed an intestinal lymphoma [standard morbidity ratio of 6.42 (95% CI = 2.9-12.2; P < 0.001)], only two kept a strict gluten-free diet after the diagnosis of celiac disease and developed the malignancy after the peridiagnosis period of 3 years, dropping therefore the standard morbidity ratio to 0.22 (95%CI = 0.02-0.88; P < 0.001). The risk of developing an intestinal lymphoma for the celiac patients that used to have dietary gluten was significant (X(2 )= 4.8 P = 0.01). These results show that a strict gluten-free diet is protective towards the development of enteropathy-associated T-cell lymphoma.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.