ArticleDigestive diseases and sciences2008
Long-term fracture risk in patients with celiac disease: a population-based study in Olmsted County, Minnesota.
Article in Digestive diseases and sciences, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 3 syntheses or guidelines pooled it, 96 citations in OpenAlex.
- European Society for the Study of Coeliac Disease (ESsCD) 2025 Updated Guidelines on the Diagnosis and Management of Coeliac Disease in Adults. Part 2: Management, Follow-Up, and Complex Disease Courses.United European gastroenterology journal · 2026Guideline
- Guideline
- ACG clinical guidelines: diagnosis and management of celiac disease.The American journal of gastroenterology · 2013Guideline
- Timing the Scan: Optimizing Screening for Osteoporosis and Risk of Fracture in Celiac Disease.The American journal of gastroenterology · 2026Observational
- Fracture risk among children and adolescents with celiac disease: a nationwide cohort study.Pediatric research · 2024Article
- More Than Three Years for Normalisation of Routine Laboratory Values after Gluten Withdrawal in Paediatric Coeliac Patients.Children (Basel, Switzerland) · 2023Article
- Evolution of bone densitometry parameters and risk of fracture in coeliac disease: a 10-year perspective.Internal and emergency medicine · 2023Article
- The Dietary and Non-Dietary Management of Osteoporosis in Adult-Onset Celiac Disease: Current Status and Practical Guidance.Nutrients · 2022Review
- Narrative Review: Nutrient Deficiencies in Adults and Children with Treated and Untreated Celiac Disease.Nutrients · 2020Review
- Osteoporosis and Osteoporotic Fractures in Gastrointestinal Disease.Journal of bone metabolism · 2018Review
- A Serological Diagnosis of Coeliac Disease Is Associated with Osteoporosis in Older Australian Adults.Nutrients · 2018Article
- Open-Capsule Budesonide for Refractory Celiac Disease.The American journal of gastroenterology · 2017Article
- Review
- Celiac Disease Does Not Influence Fracture Risk in Young Patients with Type 1 Diabetes.The Journal of pediatrics · 2016Article
- Elderly Onset Celiac Disease: A Narrative Review.Clinical medicine insights. Gastroenterology · 2016Review
- Extraintestinal manifestations of coeliac disease.Nature reviews. Gastroenterology & hepatology · 2015Review
- Practical insights into gluten-free diets.Nature reviews. Gastroenterology & hepatology · 2015Review
- Abnormal Skeletal Strength and Microarchitecture in Women With Celiac Disease.The Journal of clinical endocrinology and metabolism · 2015Article
- Trends and racial/ethnic disparities in gluten-sensitive problems in the United States: findings from the National Health and Nutrition Examination Surveys from 1988 to 2012.The American journal of gastroenterology · 2015Article
- Celiac disease and risk of fracture in adults--a review.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Celiac disease is associated with decreased bone density, but there are conflicting data regarding fracture risk. We determined the fracture incidence relative to matched controls in a population-based cohort with celiac disease before and after diagnosis. Olmsted County residents with celiac disease (n = 83) diagnosed between 1950 and 2002 were compared with 166 gender and age matched controls. Fracture histories were ascertained from each subject's medical records. Celiac disease is linked to an increased fracture risk before and after diagnosis. Before the index date, cases had a fracture rate twice that of controls (CI: 1.0-3.9, P = 0.045) and 2.5-fold greater after the index date (CI: 1.1-5.6, P = 0.026). Appendicular and axial fractures were 2.5 (CI: 0.9-6.5) and 3.2 times more likely (CI: 1.0-10.5) after the index date. These observations support a rationale for earlier detection of celiac disease, and active management of bone disease before bone effects have occurred, to reduce the persistent risk of fractures.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.