Evidence map›Paper›PMID 17934485›Full record

ReviewOncogene2007

Transcriptional control of erythropoiesis: emerging mechanisms and principles.

S-I Kim, E H Bresnick

Abstract readReview
PubMed Publisher
In one paragraph

Review in Oncogene, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 100 citations in OpenAlex.

  1. ReducedInternational journal of molecular sciences · 2026
    Article
  2. Review
  3. Review
  4. Article
  5. Multi-lineage Differentiation from Hematopoietic Stem Cells.Advances in experimental medicine and biology · 2023
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Hypoxia Pathway Proteins are Master Regulators of Erythropoiesis.International journal of molecular sciences · 2020
    Review
  11. Review
  12. Review
  13. The zebrafish: A fintastic model for hematopoietic development and disease.Wiley interdisciplinary reviews. Developmental biology · 2018
    Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Transcriptional mechanisms underlying hemoglobin synthesis.Cold Spring Harbor perspectives in medicine · 2013
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

S-I KimDepartment of Pharmacology, University of Wisconsin School of Medicine and Public Health, Medical Sciences Center, Madison, WI 53706, USA.
E H Bresnick
University of Wisconsin–Madison · US

Funding

Hematopoietic Regulation via GATA SwitchesR01DK068634 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI Emery H. Bresnick · 2006 to 2026
$7.5M
Transcriptional Control of Hemoglobin Synthesis and Erythrocyte DevelopmentR01DK050107 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI Emery H. Bresnick · 1996 to 2026
$6.1M
COACTIVATORS THAT MEDIATE BETA GLOBIN LCR FUNCTIONR01DK055700 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI BRESNICK, EMERY H. · 1999 to 2006
$1.8M
Hematopoietic Regulation Via GATA SwitchesR56DK068634 · NIDDK · UNIVERSITY OF WISCONSIN MADISON · PI BRESNICK, EMERY H. · 2005 to 2005
$109k
NIDDK NIH HHS DK50107NIDDK NIH HHS DK55700NIDDK NIH HHS DK68634
6 · The paper itself

Abstract

Transcriptional networks orchestrate fundamental biological processes, including hematopoiesis, in which hematopoietic stem cells progressively differentiate into specific progenitors cells, which in turn give rise to the diverse blood cell types. Whereas transcription factors recruit coregulators to chromatin, leading to targeted chromatin modification and recruitment of the transcriptional machinery, many questions remain unanswered regarding the underlying molecular mechanisms. Furthermore, how diverse cell type-specific transcription factors function cooperatively or antagonistically in distinct cellular contexts is poorly understood, especially since genes in higher eukaryotes commonly encompass broad chromosomal regions (100 kb and more) and are littered with dispersed regulatory sequences. In this article, we describe an important set of transcription factors and coregulators that control erythropoiesis and highlight emerging transcriptional mechanisms and principles. It is not our intent to comprehensively survey all factors implicated in the transcriptional control of erythropoiesis, but rather to underscore specific mechanisms, which have potential to be broadly relevant to transcriptional control in diverse systems.

Indexed as

AnimalsErythropoiesisGene Expression Regulation, DevelopmentalHumansRepressor ProteinsTrans-ActivatorsTranscription, GeneticRepressor ProteinsTrans-Activators

Identifiers

PMID17934485
OpenAlexW1980091579

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.