ReviewClinical microbiology reviews2007
Human infection with Fusobacterium necrophorum (Necrobacillosis), with a focus on Lemierre's syndrome.
Review in Clinical microbiology reviews, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 260 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
260 citing papers in PubMed, 3 syntheses or guidelines pooled it, 579 citations in OpenAlex.
- Epstein-Barr virus as promoter of Lemierre syndrome: systematic literature review.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024Pooled it
- Acute sore throat andBMJ open · 2021Pooled it
- A Guide to Utilization of the Microbiology Laboratory for Diagnosis of Infectious Diseases: 2018 Update by the Infectious Diseases Society of America and the American Society for Microbiology.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2018Guideline
- Genomic characterization of Fusobacterium necrophorum subsp. necrophorum strain JKSFn-26 associated with severe ovine footrot in Kashmir, India.Molecular biology reports · 2026Article
- Rare bacterial infections and metagenomics: current diagnostic and therapeutic challenges-a literature review.Infection · 2026Review
- Host-Microbe Mechanisms of Fusobacterium nucleatum in Colorectal Cancer.Molecular oral microbiology · 2026Review
- FulminantInfectious disease reports · 2026Article
- Visceral variant of Lemierre's syndrome presenting with liver abscess, hepatic vein thrombophlebitis, and septic pulmonary emboli.Oxford medical case reports · 2026Article
- Excision of the internal jugular vein in uncontrolled Lemierre's syndrome: a case report and literature review.Oral and maxillofacial surgery · 2026Review
- S1Q3T3 Pattern in Lemierre Syndrome: Acute Cor Pulmonale Masquerading as Massive Pulmonary Embolism.JACC. Case reports · 2026Article
- Article
- Incomplete Lemierre's syndrome: a case report.Journal of medical case reports · 2026Article
- A Closer Examination of Sore Throats and Their Hidden Dangers: A Case Report of Lemierre's Syndrome.Cureus · 2026Article
- Biphasic Clinical Course Revealing Lemierre's Syndrome Following Acute Pharyngotonsillitis: A Case Report.Cureus · 2026Article
- Infections Caused by Fusobacterium Species: Microbiology, Clinical Syndromes and Management: A Narrative Review.Infectious diseases and therapy · 2026Review
- Paediatric septic thrombophlebitis secondary to an otogenic infection: a single-centre retrospective case series.European journal of pediatrics · 2026Article
- Lemierre Syndrome Presenting With Septic Pulmonary Emboli: A Case Report and Diagnostic Challenges.Cureus · 2026Article
- Lemierre syndrome making an encore in the post-antibiotic era: A case report.Journal of family medicine and primary care · 2026Article
- Article
- Lemierre syndrome.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2026Article
200 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human infection with Fusobacterium necrophorum usually involves F. necrophorum subsp. funduliforme rather than F. necrophorum subsp. necrophorum, which is a common pathogen in animals. Lemierre's syndrome, or postanginal sepsis, is the most common life-threatening manifestation. Tonsillitis is followed by septic thrombophlebitis of the internal jugular vein and then a septicemia with septic emboli in lungs and other sites. Recent evidence suggests that F. necrophorum can be limited to the throat and cause persistent or recurrent tonsillitis. F. necrophorum is unique among non-spore-forming anaerobes, first for its virulence and association with Lemierre's syndrome as a monomicrobial infection and second because it seems probable that it is an exogenously acquired infection. The source of infection is unclear; suggestions include acquisition from animals or human-to-human transmission. Approximately 10% of published cases are associated with infectious mononucleosis, which may facilitate invasion. Recent work suggests that underlying thrombophilia may predispose to internal jugular vein thrombophlebitis. Lemierre's syndrome was relatively common in the preantibiotic era but seemed to virtually disappear with widespread use of antibiotics for upper respiratory tract infection. In the last 15 years there has been a rise in incidence, possibly related to restriction in antibiotic use for sore throat.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.