ArticleThe Plant cell2007
The Arabidopsis mitogen-activated protein kinase kinase MKK3 is upstream of group C mitogen-activated protein kinases and participates in pathogen signaling.
Article in The Plant cell, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 115 papers.
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115 citing papers in PubMed.
- Expression pattern of the 10 mitogen-activated protein kinase kinases (MAPKK) encoded onPlant signaling & behavior · 2026Article
- Synthetic Biology of Plants and Microbes for Agriculture, Environment, and Future Applications.Chemical reviews · 2026Review
- Transcriptome and Hormone Analysis Revealed Jasmonic Acid-Mediated Immune Responses of Potato (Antioxidants (Basel, Switzerland) · 2026Article
- ROS homeostasis and cell wall biosynthesis pathway are involved in female inflorescence development of birch (Betula platyphylla).BMC plant biology · 2025Article
- CaBMC plant biology · 2025Article
- Nitrate activates an MKK3-dependent MAPK module via NLP transcription factors in Arabidopsis.The Plant journal : for cell and molecular biology · 2025Article
- The MKK3 module integrates nitrate and light signals to modulate secondary dormancy inProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Review
- Comparisons of two receptor-MAPK pathways in a single cell-type reveal mechanisms of signalling specificity.Nature plants · 2024Article
- The MKK3 MAPK cascade integrates temperature and after-ripening signals to modulate seed germination.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Identification and analysis of MAPK cascade gene families of Camellia oleifera and their roles in response to cold stress.Molecular biology reports · 2024Article
- MKK3 Cascade Regulates Seed Dormancy Through a Negative Feedback Loop Modulating ABA Signal in Rice.Rice (New York, N.Y.) · 2024Article
- Uncovering molecular mechanisms involved in microbial volatile compounds-induced stomatal closure in Arabidopsis thaliana.Plant molecular biology · 2023Article
- Harnessing the role of mitogen-activated protein kinases against abiotic stresses in plants.Frontiers in plant science · 2023Review
- Mitogen-activated protein kinase 14-mediated phosphorylation of MaMYB4 negatively regulates banana fruit ripening.Horticulture research · 2023Article
- Identification and Expression Analysis of MPK and MKK Gene Families in Pecan (International journal of molecular sciences · 2022Article
- Genome-wide identification and characterization of the MAPKKK, MKK, and MPK families in Chinese elite maize inbred line Huangzaosi.The plant genome · 2022Article
- Plant Responses to Herbivory, Wounding, and Infection.International journal of molecular sciences · 2022Review
- Mitogen-Activated Protein Kinase and Substrate Identification in Plant Growth and Development.International journal of molecular sciences · 2022Review
- Try or Die: Dynamics of Plant Respiration and How to Survive Low Oxygen Conditions.Plants (Basel, Switzerland) · 2022Review
55 more citing papers are in PubMed but not listed here.
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8 authors.
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Abstract
Although the Arabidopsis thaliana genome contains genes encoding 20 mitogen-activated protein kinases (MAPKs) and 10 MAPK kinases (MAPKKs), most of them are still functionally uncharacterized. In this work, we analyzed the function of the group B MAPK kinase, MKK3. Transgenic ProMKK3:GUS lines showed basal expression in vascular tissues that was strongly induced by Pseudomonas syringae pv tomato strain DC3000 (Pst DC3000) infection but not by abiotic stresses. The growth of virulent Pst DC3000 was increased in mkk3 knockout plants and decreased in MKK3-overexpressing plants. Moreover, MKK3 overexpression lines showed increased expression of several PR genes. By yeast two-hybrid analysis, coimmunoprecipitation, and protein kinase assays, MKK3 was revealed to be an upstream activator of the group C MAPKs MPK1, MPK2, MPK7, and MPK14. Flagellin-derived flg22 peptide strongly activated MPK6 but resulted in poor activation of MPK7. By contrast, MPK6 and MPK7 were both activated by H(2)O(2), but only MPK7 activation was enhanced by MKK3. In agreement with the notion that MKK3 regulates the expression of PR genes, ProPR1:GUS expression was strongly enhanced by coexpression of MKK3-MPK7. Our results reveal that the MKK3 pathway plays a role in pathogen defense and further underscore the importance and complexity of MAPK signaling in plant stress responses.
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