ArticleJournal of bacteriology2007
A horizontal gene transfer event defines two distinct groups within Burkholderia pseudomallei that have dissimilar geographic distributions.
Article in Journal of bacteriology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.
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Who cites it
68 citing papers in PubMed.
- Emergence of Human and Animal Melioidosis in Southern Africa, 2018-2021.Tropical medicine and infectious disease · 2026Article
- Genomic characterization of an environmental Burkholderia thailandensis strain from Kerala, India reveals virulence and antimicrobial resistance signatures.BMC genomics · 2025Article
- Melioidosis in goats at a single Australian farm was caused by multiple diverse lineages of Burkholderia pseudomallei present in soil.PLoS neglected tropical diseases · 2024Article
- A molecular epidemiological analysis of Burkholderia pseudomallei in southern Thailand.PLoS neglected tropical diseases · 2024Article
- The Genomic Epidemiology of ClinicalPathogens (Basel, Switzerland) · 2024Article
- Epidemiology and genetic diversity of Burkholderia pseudomallei from Riau Province, Indonesia.PLoS neglected tropical diseases · 2024Article
- Phylogeographic characterization of Burkholderia pseudomallei isolated from Bangladesh.PLoS neglected tropical diseases · 2023Article
- Melioidosis Queensland: An analysis of clinical outcomes and genomic factors.PLoS neglected tropical diseases · 2023Article
- Under-Reporting Cases and Deaths from Melioidosis: A Retrospective Finding in Songkhla and Phatthalung Province of Southern Thailand, 2014-2020.Tropical medicine and infectious disease · 2023Article
- Pathogenicity and virulence ofVirulence · 2022Review
- Natural infection of leptospirosis and melioidosis in long-tailed macaques (Macaca fascicularis) in Thailand.The Journal of veterinary medical science · 2022Article
- Article
- Biogeography and genetic diversity of clinical isolates of Burkholderia pseudomallei in Sri Lanka.PLoS neglected tropical diseases · 2021Article
- Comparative virulence of three different strains of Burkholderia pseudomallei in an aerosol non-human primate model.PLoS neglected tropical diseases · 2021Article
- Whole-genome comparative analysis of MalaysianMicrobial genomics · 2021Article
- Characterization ofVeterinary world · 2020Article
- Human Melioidosis.Clinical microbiology reviews · 2020Review
- An Evolutionary Arms Race BetweenFrontiers in microbiology · 2020Review
- Burkholderia pseudomallei, the causative agent of melioidosis, is rare but ecologically established and widely dispersed in the environment in Puerto Rico.PLoS neglected tropical diseases · 2019Article
- Opportunistic pathogens and large microbial diversity detected in source-to-distribution drinking water of three remote communities in Northern Australia.PLoS neglected tropical diseases · 2019Article
8 more citing papers are in PubMed but not listed here.
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14 authors.
Funding
Abstract
Burkholderia pseudomallei is the etiologic agent of melioidosis. Many disease manifestations are associated with melioidosis, and the mechanisms causing this variation are unknown; genomic differences among strains offer one explanation. We compared the genome sequences of two strains of B. pseudomallei: the original reference strain K96243 from Thailand and strain MSHR305 from Australia. We identified a variable homologous region between the two strains. This region was previously identified in comparisons of the genome of B. pseudomallei strain K96243 with the genome of strain E264 from the closely related B. thailandensis. In that comparison, K96243 was shown to possess a horizontally acquired Yersinia-like fimbrial (YLF) gene cluster. Here, we show that the homologous genomic region in B. pseudomallei strain 305 is similar to that previously identified in B. thailandensis strain E264. We have named this region in B. pseudomallei strain 305 the B. thailandensis-like flagellum and chemotaxis (BTFC) gene cluster. We screened for these different genomic components across additional genome sequences and 571 B. pseudomallei DNA extracts obtained from regions of endemicity. These alternate genomic states define two distinct groups within B. pseudomallei: all strains contained either the BTFC gene cluster (group BTFC) or the YLF gene cluster (group YLF). These two groups have distinct geographic distributions: group BTFC is dominant in Australia, and group YLF is dominant in Thailand and elsewhere. In addition, clinical isolates are more likely to belong to group YLF, whereas environmental isolates are more likely to belong to group BTFC. These groups should be further characterized in an animal model.
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