ArticleBiophysical journal2008
Propagation of mechanical stress through the actin cytoskeleton toward focal adhesions: model and experiment.
Article in Biophysical journal, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed.
- Dynamic mechanisms for membrane skeleton transitions.Journal of cell science · 2025Article
- Mechanically induced topological transition of spectrin regulates its distribution in the mammalian cell cortex.Nature communications · 2024Article
- Dynamic mechanisms for membrane skeleton transitions.bioRxiv : the preprint server for biology · 2024Article
- Proposing a Caputo-Land System for active tension. Capturing variable viscoelasticity.Heliyon · 2024Article
- From stress fiber to focal adhesion: a role of actin crosslinkers in force transmission.Frontiers in cell and developmental biology · 2024Review
- Recent advances in single-cell subcellular sampling.Chemical communications (Cambridge, England) · 2023Review
- The role of the dystrophin glycoprotein complex in muscle cell mechanotransduction.Communications biology · 2022Review
- Elasticity of podosome actin networks produces nanonewton protrusive forces.Nature communications · 2022Article
- Fluid transport in the brain.Physiological reviews · 2022Review
- Quantifying force transmission through fibroblasts: changes of traction forces under external shearing.European biophysics journal : EBJ · 2022Article
- Viscoelasticity, Like Forces, Plays a Role in Mechanotransduction.Frontiers in cell and developmental biology · 2022Review
- Engineering Breast Cancer Cells and hUMSCs Microenvironment in 2D and 3D Scaffolds: A Mechanical Study Approach of Stem Cells in Anticancer Therapy.Bioengineering (Basel, Switzerland) · 2021Article
- Two Complementary Signaling Pathways Depict Eukaryotic Chemotaxis: A Mechanochemical Coupling Model.Frontiers in cell and developmental biology · 2021Article
- Computational models of migration modes improve our understanding of metastasis.APL bioengineering · 2020Review
- Adjustable viscoelasticity allows for efficient collective cell migration.Seminars in cell & developmental biology · 2019Review
- Automatic directional analysis of cell fluorescence images and morphological modeling of microfilaments.Medical & biological engineering & computing · 2019Article
- Effect of equiaxial cyclic strain on cardiomyogenic induction in mesenchymal stem cells.Progress in biomaterials · 2018Article
- Wetting of soft superhydrophobic micropillar arrays.Soft matter · 2018Article
- Random Motion of Chromatin Is Influenced by Lamin A Interconnections.Biophysical journal · 2018Article
- Cellular mechanosensing of the biophysical microenvironment: A review of mathematical models of biophysical regulation of cell responses.Physics of life reviews · 2017Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We investigate both theoretically and experimentally how stress is propagated through the actin cytoskeleton of adherent cells and consequentially distributed at sites of focal adhesions (FAs). The actin cytoskeleton is modeled as a two-dimensional cable network with different lattice geometries. Both prestrain, resulting from actomyosin contractility, and central application of external force, lead to finite forces at the FAs that are largely independent of the lattice geometry, but strongly depend on the exact spatial distribution of the FAs. The simulation results compare favorably with experiments with adherent fibroblasts onto which lateral force is exerted using a microfabricated pillar. For elliptical cells, central application of external force along the long axis leads to two large stress regions located obliquely opposite to the pulling direction. For elliptical cells pulled along the short axis as well as for circular cells, there is only one region of large stress opposite to the direction of pull. If in the computer simulations FAs are allowed to rupture under force for elliptically elongated and circular cell shapes, then morphologies arise which are typical for migrating fibroblasts and keratocytes, respectively. The same effect can be obtained also by internally generated force, suggesting a mechanism by which cells can control their migration morphologies.
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