ArticleNucleic acids research2008
ProSAS: a database for analyzing alternative splicing in the context of protein structures.
Article in Nucleic acids research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Loss of LEFKOTHEA Leads to Global Transcriptional and Post-Transcriptional Changes in Gene Expression During Early Light Response.Plants (Basel, Switzerland) · 2026Article
- APPRIS: selecting functionally important isoforms.Nucleic acids research · 2022Article
- DoChaP: the domain change presenter.Nucleic acids research · 2021Article
- Exploring the functional impact of alternative splicing on human protein isoforms using available annotation sources.Briefings in bioinformatics · 2019Review
- ASpedia: a comprehensive encyclopedia of human alternative splicing.Nucleic acids research · 2018Article
- Function of alternative splicing.Gene · 2013Review
- Alternative splicing for diseases, cancers, drugs, and databases.TheScientificWorldJournal · 2013Review
- DBATE: database of alternative transcripts expression.Database : the journal of biological databases and curation · 2013Article
- APPRIS: annotation of principal and alternative splice isoforms.Nucleic acids research · 2013Article
- MAISTAS: a tool for automatic structural evaluation of alternative splicing products.Bioinformatics (Oxford, England) · 2011Article
- ASPicDB: a database of annotated transcript and protein variants generated by alternative splicing.Nucleic acids research · 2011Article
- Genome-wide data-mining of candidate human splice translational efficiency polymorphisms (STEPs) and an online database.PloS one · 2010Article
- Into the unknown: expression profiling without genome sequence information in CHO by next generation sequencing.Nucleic acids research · 2010Article
- Genomic landscape of developing male germ cells.Birth defects research. Part C, Embryo today : reviews · 2009Review
- Divergence of exonic splicing elements after gene duplication and the impact on gene structures.Genome biology · 2009Article
- AS-ALPS: a database for analyzing the effects of alternative splicing on protein structure, interaction and network in human and mouse.Nucleic acids research · 2009Article
- ExDom: an integrated database for comparative analysis of the exon-intron structures of protein domains in eukaryotes.Nucleic acids research · 2009Article
- Alternative splicing and protein structure evolution.Nucleic acids research · 2008Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alternative splicing is known to be one of the major sources for functional diversity in higher eukaryotes. Several splicing isoforms have been characterized in the literature that play important roles in cellular processes like apoptosis or signal transduction pathways. Splicing events can often be detected on the mRNA level by large-scale cDNA or EST experiments and such data is collected and annotated in several databases. Nevertheless, the effects of splicing on the structure of a protein are largely unknown. The ProSAS (Protein Structure and Alternative Splicing) database fills this gap and provides a unified resource for analyzing effects of alternative splicing events in the context of protein structures. ProSAS comprehensively annotates and models protein structures for several Ensembl genomes as well as SwissProt entries harbouring splicing events. Alternative isoforms annotated in Ensembl or SwissProt can be analyzed on the protein structure and protein function level using an intuitive user interface that provides several features and tools for a structure-based analysis of alternative splicing events. The ProSAS database is freely accessible at http://www.bio.ifi.lmu.de/ProSAS.
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