ArticleThe EMBO journal2007
Critical roles for a genetic code alteration in the evolution of the genus Candida.
Article in The EMBO journal, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed.
- Mistranslation protects against lifespan reduction due to mating in Drosophila melanogaster females.G3 (Bethesda, Md.) · 2026Article
- Impact of tRNA-induced proline-to-serine mistranslation on the transcriptome of Drosophila melanogaster.G3 (Bethesda, Md.) · 2024Article
- Impact of tRNA-induced proline-to-serine mistranslation on the transcriptome ofbioRxiv : the preprint server for biology · 2024Article
- Suppressors of mRNA Decapping Defects Restore Growth Without Major Effects on mRNA Decay Rates or Abundance.Genetics · 2020Article
- Aminoacyl-tRNA synthetases.RNA (New York, N.Y.) · 2020Review
- Review
- Codon misreading tRNAs promote tumor growth in mice.RNA biology · 2018Article
- Errors in protein synthesis increase the level of saturated fatty acids and affect the overall lipid profiles of yeast.PloS one · 2018Article
- Efforts and Challenges in Engineering the Genetic Code.Life (Basel, Switzerland) · 2017Review
- How tRNAs dictate nuclear codon reassignments: Only a few can capture non-cognate codons.RNA biology · 2017Review
- Proteome-wide measurement of non-canonical bacterial mistranslation by quantitative mass spectrometry of protein modifications.Scientific reports · 2016Article
- C-terminal Domain of Leucyl-tRNA Synthetase from Pathogenic Candida albicans Recognizes both tRNASer and tRNALeu.The Journal of biological chemistry · 2016Article
- The Fungus Candida albicans Tolerates Ambiguity at Multiple Codons.Frontiers in microbiology · 2016Article
- Genetic code evolution reveals the neutral emergence of mutational robustness, and information as an evolutionary constraint.Life (Basel, Switzerland) · 2015Article
- Evolution of Robustness to Protein Mistranslation by Accelerated Protein Turnover.PLoS biology · 2015Article
- The Candida pathogenic species complex.Cold Spring Harbor perspectives in medicine · 2014Review
- Mutations enabling displacement of tryptophan by 4-fluorotryptophan as a canonical amino acid of the genetic code.Genome biology and evolution · 2014Article
- Aminoacylation and translational quality control strategy employed by leucyl-tRNA synthetase from a human pathogen with genetic code ambiguity.Nucleic acids research · 2013Article
- Molecular reconstruction of a fungal genetic code alteration.RNA biology · 2013Article
- Simplification of the genetic code: restricted diversity of genetically encoded amino acids.Nucleic acids research · 2012Article
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During the last 30 years, several alterations to the standard genetic code have been discovered in various bacterial and eukaryotic species. Sense and nonsense codons have been reassigned or reprogrammed to expand the genetic code to selenocysteine and pyrrolysine. These discoveries highlight unexpected flexibility in the genetic code, but do not elucidate how the organisms survived the proteome chaos generated by codon identity redefinition. In order to shed new light on this question, we have reconstructed a Candida genetic code alteration in Saccharomyces cerevisiae and used a combination of DNA microarrays, proteomics and genetics approaches to evaluate its impact on gene expression, adaptation and sexual reproduction. This genetic manipulation blocked mating, locked yeast in a diploid state, remodelled gene expression and created stress cross-protection that generated adaptive advantages under environmental challenging conditions. This study highlights unanticipated roles for codon identity redefinition during the evolution of the genus Candida, and strongly suggests that genetic code alterations create genetic barriers that speed up speciation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.