Evidence map›Paper›PMID 17932292›Full record

ArticleScience (New York, N.Y.)2007

The Chlamydomonas genome reveals the evolution of key animal and plant functions.

Sabeeha S Merchant, Simon E Prochnik, Olivier Vallon, Elizabeth H Harris, Steven J Karpowicz, George B Witman, Astrid Terry, Asaf Salamov, Lillian K Fritz-Laylin, Laurence Maréchal-Drouard and 107 more

Open access · greenAbstract read
In one paragraph

Article in Science (New York, N.Y.), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1,203 papers.

0numbers the graph read from it
0cells of the map it votes in
1,203citing papers in PubMed
52.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1,203 citing papers in PubMed, 2,670 citations in OpenAlex.

  1. Article
  2. Genome analysis of the glycosphingolipid-producing green alga tetraselmis sp. NKG400013.DNA research : an international journal for rapid publication of reports on genes and genomes · 2026
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  3. Adaptive responses ofBiotechnology reports (Amsterdam, Netherlands) · 2026
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  14. Science advances · 2026
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1,143 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

117 authors at 7 institutions in 3 countries.

Sabeeha S MerchantDepartment of Chemistry and Biochemistry, University of California at Los Angeles, Los Angeles, CA 90095, USA.
Simon E Prochnik
Olivier Vallon
Elizabeth H Harris
Steven J Karpowicz
George B Witman
Astrid Terry
Asaf Salamov
Lillian K Fritz-Laylin
Laurence Maréchal-Drouard
Wallace F Marshall
Liang-Hu Qu
David R Nelson
Anton A Sanderfoot
Martin H Spalding
Vladimir V Kapitonov
Qinghu Ren
Patrick Ferris
Erika Lindquist
Harris Shapiro
Susan M Lucas
Jane Grimwood
Jeremy Schmutz
Pierre Cardol
Heriberto Cerutti
Guillaume Chanfreau
Chun-Long Chen
Valérie Cognat
Martin T Croft
Rachel Dent
Susan Dutcher
Emilio Fernández
Hideya Fukuzawa
David González-Ballester
Diego González-Halphen
Armin Hallmann
Marc Hanikenne
Michael Hippler
William Inwood
Kamel Jabbari
Ming Kalanon
Richard Kuras
Paul A Lefebvre
Stéphane D Lemaire
Alexey V Lobanov
Martin Lohr
Andrea Manuell
Iris Meier
Laurens Mets
Maria Mittag
Telsa Mittelmeier
James V Moroney
Jeffrey Moseley
Carolyn Napoli
Aurora M Nedelcu
Krishna Niyogi
Sergey V Novoselov
Ian T Paulsen
Greg Pazour
Saul Purton
Jean-Philippe Ral
Diego Mauricio Riaño-Pachón
Wayne Riekhof
Linda Rymarquis
Michael Schroda
David Stern
James Umen
Robert Willows
Nedra Wilson
Sara Lana Zimmer
Jens Allmer
Janneke Balk
Katerina Bisova
Chong-Jian Chen
Marek Elias
Karla Gendler
Charles Hauser
Mary Rose Lamb
Heidi Ledford
Joanne C Long
Jun Minagawa
M Dudley Page
Junmin Pan
Wirulda Pootakham
Sanja Roje
Annkatrin Rose
Eric Stahlberg
Aimee M Terauchi
Pinfen Yang
Steven Ball
Chris Bowler
Carol L Dieckmann
Vadim N Gladyshev
Pamela Green
Richard Jorgensen
Stephen Mayfield
Bernd Mueller-Roeber
Sathish Rajamani
Richard T Sayre
Peter Brokstein
Inna Dubchak
David Goodstein
Leila Hornick
Y Wayne Huang
Jinal Jhaveri
Yigong Luo
Diego Martínez
Wing Chi Abby Ngau
Bobby Otillar
Alexander Poliakov
Aaron Porter
Lukasz Szajkowski
Gregory Werner
Kemin Zhou
Igor V Grigoriev
Daniel S Rokhsar
Arthur R Grossman
University of California, Los Angeles · USDuke University · USUniversity of Massachusetts Chan Medical School · USJoint Genome Institute · USStanford Medicine · USLos Alamos National Laboratory · USUniversity of California, Berkeley · US

Funding

UCLA NIGMS T32 Program AssessmentT32GM007185 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI TORRES, JORGE · 1985 to 2020
$21.7M
Flagellar Motility and AssemlbyR37GM030626 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI WITMAN, GEORGE B · 2007 to 2016
$6.3M
GENETIC ANALYSIS OF BASAL BODY FUNCTIONR01GM032843 · NIGMS · WASHINGTON UNIVERSITY · PI DUTCHER, SUSAN K · 1985 to 2018
$5.9M
Nutritional Cu Signaling and HomeostasisR01GM042143 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SABEEHA MERCHANT · 1995 to 2026
$4.6M
Nutritional Copper Signaling and HomeostasisR37GM042143 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MERCHANT, SABEEHA · 2011 to 2020
$4.3M
RNA-Mediated Silencing: Mechanisms and Biological Roles in ChlamydomonasR01GM062915 · NIGMS · UNIVERSITY OF NEBRASKA LINCOLN · PI CERUTTI, HERIBERTO · 2001 to 2009
$2.0M
CU-DEPENDENT TRANSCRIPTIONAL REGULATIONR29GM042143 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MERCHANT, SABEEHA · 1989 to 1993
–
NIGMS NIH HHS GM07185NIGMS NIH HHS GM42143NIGMS NIH HHS R01 GM032843NIGMS NIH HHS R01 GM042143NIGMS NIH HHS R01 GM062915NIGMS NIH HHS R37 GM030626NIGMS NIH HHS R37 GM042143NIGMS NIH HHS T32 GM007185
6 · The paper itself

Abstract

Chlamydomonas reinhardtii is a unicellular green alga whose lineage diverged from land plants over 1 billion years ago. It is a model system for studying chloroplast-based photosynthesis, as well as the structure, assembly, and function of eukaryotic flagella (cilia), which were inherited from the common ancestor of plants and animals, but lost in land plants. We sequenced the approximately 120-megabase nuclear genome of Chlamydomonas and performed comparative phylogenomic analyses, identifying genes encoding uncharacterized proteins that are likely associated with the function and biogenesis of chloroplasts or eukaryotic flagella. Analyses of the Chlamydomonas genome advance our understanding of the ancestral eukaryotic cell, reveal previously unknown genes associated with photosynthetic and flagellar functions, and establish links between ciliopathy and the composition and function of flagella.

Indexed as

Biological EvolutionGenomeAlgal ProteinsAnimalsChlamydomonas reinhardtiiChloroplastsComputational BiologyDNA, AlgalFlagellaGenesGenomicsMembrane Transport ProteinsMolecular Sequence DataMultigene FamilyPhotosynthesisPhylogenyAlgal ProteinsDNA, AlgalMembrane Transport ProteinsProteome

Identifiers

PMID17932292
PMCPMC2875087
OpenAlexW2021795499

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.