ArticleThe Journal of physiology2007
Crossbridge properties during force enhancement by slow stretching in single intact frog muscle fibres.
Article in The Journal of physiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Integrated Opto-Biomechatronics For Single Muscle Fibre Structure-Function Assessment: The MyoRobot 3.0.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Stretch activation combats force loss from fatigue in fast-contracting mouse skeletal muscle fibers.The Journal of general physiology · 2025Article
- Eccentric muscle contractions: from single muscle fibre to whole muscle mechanics.Pflugers Archiv : European journal of physiology · 2023Review
- The load dependence and the force-velocity relation in intact myosin filaments from skeletal and smooth muscles.American journal of physiology. Cell physiology · 2020Article
- A myosin-based mechanism for stretch activation and its possible role revealed by varying phosphate concentration in fast and slow mouse skeletal muscle fibers.American journal of physiology. Cell physiology · 2019Article
- Do Actomyosin Single-Molecule Mechanics Data Predict Mechanics of Contracting Muscle?International journal of molecular sciences · 2018Review
- The active force-length relationship is invisible during extensive eccentric contractions in skinned skeletal muscle fibres.Proceedings. Biological sciences · 2017Article
- Poorly understood aspects of striated muscle contraction.BioMed research international · 2015Review
- Force enhancement in lengthening contractions of cat soleus muscle in situ: transient and steady-state aspects.Physiological reports · 2013Article
- An embryonic myosin isoform enables stretch activation and cyclical power in Drosophila jump muscle.Biophysical journal · 2013Article
- Mechanism of force enhancement during stretching of skeletal muscle fibres investigated by high time-resolved stiffness measurements.Journal of muscle research and cell motility · 2013Article
- Mechanism of force enhancement during and after lengthening of active muscle: a temperature dependence study.Journal of muscle research and cell motility · 2012Article
- The mechanisms of the residual force enhancement after stretch of skeletal muscle: non-uniformity in half-sarcomeres and stiffness of titin.Proceedings. Biological sciences · 2012Review
- Mechanisms Of Residual Force Enhancement In Skeletal Muscle: Insights From Experiments And Mathematical Models.Biophysical reviews · 2011Article
- A mathematical model of muscle containing heterogeneous half-sarcomeres exhibits residual force enhancement.PLoS computational biology · 2011Article
- Crossbridge and filament compliance in muscle: implications for tension generation and lever arm swing.Journal of muscle research and cell motility · 2010Review
- Force and power generating mechanism(s) in active muscle as revealed from temperature perturbation studies.The Journal of physiology · 2010Review
- Is the cross-bridge stiffness proportional to tension during muscle fiber activation?Biophysical journal · 2010Article
- Reversal of the myosin power stroke induced by fast stretching of intact skeletal muscle fibers.Biophysical journal · 2009Article
- Insights into the kinetics of Ca2+-regulated contraction and relaxation from myofibril studies.Pflugers Archiv : European journal of physiology · 2009Article
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5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mechanism of force enhancement during lengthening was investigated on single frog muscle fibres by using fast stretches to measure the rupture tension of the crossbridge ensemble. Fast stretches were applied to one end of the activated fibre and force responses were measured at the other. Sarcomere length was measured by a striation follower device. Fast stretching induced a linear increase of tension that reached a peak and fell before the end of the stretch indicating that a sudden increase of fibre compliance occurred due to forced crossbridge detachment induced by the fast loading. The peak tension (critical tension, Pc) and the sarcomere length needed to reach Pc (critical length, Lc) were measured at various tensions during the isometric tetanus rise and during force enhancement by slow lengthening. The data showed that Pc was proportional to the tension generated by the fibre under both isometric and slow lengthening conditions. However, for a given tension increase, Pc was 6.5 times greater during isometric than during lengthening conditions. Isometric critical length was 13.04 +/- 0.17 nm per half-sarcomere (nm hs(-1)) independently of tension. During slow lengthening critical length fell as the force enhancement increased. For 90% enhancement, Lc reduced to 8.19 +/- 0.039 nm hs(-1). Assuming that the rupture force of the individual crossbridge is constant, these data indicate that the increase of crossbridge number during lengthening accounts for only 15.4% of the total force enhancement. The remaining 84.6% is accounted for by the increased mean strain of the crossbridges.
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