ArticleThe Journal of physiology2007
Olfactory marker protein modulates the cAMP kinetics of the odour-induced response in cilia of mouse olfactory receptor neurons.
Article in The Journal of physiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed, 88 citations in OpenAlex.
- Molecular Evidence for the Parallel Evolution of Anosmia in Multiple Odontoceti (Toothed Whales) Clades.Genes · 2026Article
- Immature olfactory sensory neurons are intrinsically excitable and show maturation-dependent changes in voltage-gated NaPflugers Archiv : European journal of physiology · 2026Article
- The CaThe Journal of physiology · 2024Article
- Olfactory marker protein regulation of glucagon secretion in hyperglycemia.Experimental & molecular medicine · 2022Article
- Dermal Olfactory Receptor OR51B5 Is Essential for Survival and Collagen Synthesis in Human Dermal Fibroblast (Hs68 Cells).International journal of molecular sciences · 2021Article
- Olfactory marker protein interacts with adenosine nucleotide derivatives.Biochemistry and biophysics reports · 2021Article
- Olfaction of aquatic amniotes.Cell and tissue research · 2021Review
- The cyclic AMP signaling pathway in the rodent main olfactory system.Cell and tissue research · 2021Review
- The functional relevance of olfactory marker protein in the vertebrate olfactory system: a never-ending story.Cell and tissue research · 2021Review
- Amyotrophic Lateral Sclerosis Is Accompanied by Protein Derangements in the Olfactory Bulb-Tract Axis.International journal of molecular sciences · 2020Article
- Immunocytochemical Localization of Olfactory-signaling Molecules in Human and Rat Spermatozoa.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2020Article
- Olfactory marker protein directly buffers cAMP to avoid depolarization-induced silencing of olfactory receptor neurons.Nature communications · 2020Article
- Alzheimer's Disease: What Can We Learn From the Peripheral Olfactory System?Frontiers in neuroscience · 2020Review
- Olfactory receptor neurons express olfactory marker protein but not calpain 5 from the same genomic locus.Molecular brain · 2019Article
- Article
- Olfactory marker protein (OMP) regulates formation and refinement of the olfactory glomerular map.Nature communications · 2018Article
- Olfactory marker protein regulates prolactin secretion and production by modulating CaExperimental & molecular medicine · 2018Article
- Cell type-dependent axonal localization of translational regulators and mRNA in mouse peripheral olfactory neurons.The Journal of comparative neurology · 2017Article
- Cilia- and Flagella-Associated Protein 69 Regulates Olfactory Transduction Kinetics in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Simultaneous Loss of NCKX4 and CNG Channel Desensitization Impairs Olfactory Sensitivity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
Olfactory marker protein (OMP), a phylogenetically conserved protein, is highly, and almost exclusively, expressed in vertebrate olfactory receptor neurons (ORNs). Although OMP is widely used as a marker for ORNs, its function has remained largely elusive. Here we used suction-pipette recordings from isolated ORNs of OMP(-/-) mice to investigate its role in olfactory transduction. Vertebrate olfactory transduction is initiated when odourants bind to receptor proteins to activate an adenylyl cyclase via a G protein-coupled signalling pathway. This leads to an increase in cAMP and the opening of a cyclic nucleotide-gated (CNG), non-selective cation channel which depolarizes the cells. Ca(2+) influx through the CNG channel in turn activates a Ca(2+)-activated Cl(-) channel, causing a Cl(-) efflux and further depolarization. In the absence of OMP, the time-to-transient-peak of the response, the latency to first spike, and the response termination were slowed 2- to 8-fold, indicating its role in regulating olfactory response kinetics and termination. This phenotype persisted in OMP(-/-) ORNs even in low external Ca(2+) solution chosen to prevent Cl(-) channel activation, suggesting OMP acts upstream of Cl(-) channel activation. Furthermore, the response kinetics in cilia are virtually indistinguishable between OMP(-/-) and wild-type ORNs when intracellular cAMP level was elevated by the phospho-diesterase inhibitor, IBMX, suggesting OMP acts upstream of cAMP production. Together, our results suggest a role for OMP in regulating the kinetics and termination of olfactory responses, implicating a novel mechanism for fast and robust response termination to ensure the temporal resolution of the odour stimulus. These observations also help explain the deficits in odour detection threshold and odour quality discrimination seen in the OMP(-/-) mice.
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