ArticleThe Journal of physiology2007
Depolarization of isolated horizontal cells of fish acidifies their immediate surrounding by activating V-ATPase.
Article in The Journal of physiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 40 citations in OpenAlex.
- Vacuolar-ATPase-mediated muscle acidification caused muscular mechanical nociceptive hypersensitivity after chronic stress in rats, which involved extracellular matrix proteoglycan and ASIC3.Scientific reports · 2023Article
- Calcium Channels in Retinal Function and Disease.Annual review of vision science · 2022Review
- Article
- Sources of protons and a role for bicarbonate in inhibitory feedback from horizontal cells to cones in Ambystoma tigrinum retina.The Journal of physiology · 2016Article
- Lateral Inhibition in the Vertebrate Retina: The Case of the Missing Neurotransmitter.PLoS biology · 2015Article
- Extracellular ATP hydrolysis inhibits synaptic transmission by increasing ph buffering in the synaptic cleft.PLoS biology · 2014Article
- Fluorescent imaging reports an extracellular alkalinization induced by glutamatergic activation of isolated retinal horizontal cells.Journal of neurophysiology · 2014Article
- Imaging an optogenetic pH sensor reveals that protons mediate lateral inhibition in the retina.Nature neuroscience · 2014Article
- Calcium channels in rat horizontal cells regulate feedback inhibition of photoreceptors through an unconventional GABA- and pH-sensitive mechanism.The Journal of physiology · 2013Article
- Endogenous voltage gradients as mediators of cell-cell communication: strategies for investigating bioelectrical signals during pattern formation.Cell and tissue research · 2013Review
- Distinctive patterns of alterations in proton efflux from goldfish retinal horizontal cells monitored with self-referencing H⁺-selective electrodes.The European journal of neuroscience · 2012Article
- Lateral interactions in the outer retina.Progress in retinal and eye research · 2012Review
- Acidification of the synaptic cleft of cone photoreceptor terminal controls the amount of transmitter release, thereby forming the receptive field surround in the vertebrate retina.The journal of physiological sciences : JPS · 2012Review
- Extracellular pH dynamics of retinal horizontal cells examined using electrochemical and fluorometric methods.Journal of neurophysiology · 2012Article
- Regulation of cell behavior and tissue patterning by bioelectrical signals: challenges and opportunities for biomedical engineering.Annual review of biomedical engineering · 2012Review
- Hydrogen sulfide protects the retina from light-induced degeneration by the modulation of Ca2+ influx.The Journal of biological chemistry · 2011Article
- V-ATPase-dependent ectodermal voltage and pH regionalization are required for craniofacial morphogenesis.Developmental dynamics : an official publication of the American Association of Anatomists · 2011Article
- A positive feedback synapse from retinal horizontal cells to cone photoreceptors.PLoS biology · 2011Article
- Gating, permselectivity and pH-dependent modulation of channels formed by connexin57, a major connexin of horizontal cells in the mouse retina.The Journal of physiology · 2009Article
- Bioelectric mechanisms in regeneration: Unique aspects and future perspectives.Seminars in cell & developmental biology · 2009Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In order to interpret the formation of receptive field surrounds in retinal neurons, a proton-mediated mechanism was proposed to mediate feedback from horizontal cells (HCs) to cone photoreceptors. To verify the idea that depolarized HCs release protons, we measured, by a fluorescence ratiometric technique, the pH of the immediate external surface (pHs) of HCs isolated from the carp or goldfish retina. When HCs stained by 5-hexadecanoylaminofluorescein, a pH-sensitive lipophilicdye, were depolarized by bath-application of kainate or high-K+ medium, pHs was lowered. The amount of pHs change was monotonically dependent on the degree of depolarization, as much as 0.21 +/- 0.05 pH units by 100 mV depolarization (induced by 100 mm K+). Acidification was suppressed by 400 nm bafilomycin A1, a specific inhibitor of the vacuolar type H+ pump (V-ATPase), suggesting that depolarization released protons from HCs via the voltage-sensitive H+ pump. Immunocytochemical analysis, using an anti-V-ATPase antibody, revealed the existence of V-ATPase in dissociated HCs. These results support the hypothesis that the feedback from HCs to cones could be proton mediated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.