ArticleNucleic acids research2007
Extent to which hairpin opening by the Artemis:DNA-PKcs complex can contribute to junctional diversity in V(D)J recombination.
Article in Nucleic acids research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- A Synthetic Platform for Antibody Junctional Diversification Beyond Natural Constraints.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Generating combinatorial diversity via engineered V(D)J-like recombination in Saccharomyces cerevisiae.Nature communications · 2025Article
- Statistical analysis of repertoire data demonstrates the influence of microhomology in V(D)J recombination.Nucleic acids research · 2025Article
- Article
- B cell abnormalities and autoantibody production in patients with partial RAG deficiency.Frontiers in immunology · 2023Review
- Dynamics of the Artemis and DNA-PKcs Complex in the Repair of Double-Strand Breaks.Journal of molecular biology · 2022Review
- Article
- RAG1 splicing mutation causes enhanced B cell differentiation and autoantibody production.JCI insight · 2021Article
- Nucleotide Pool Imbalance and Antibody Gene Diversification.Vaccines · 2021Review
- Temporally uncoupled signal and coding joint formation in human V(D)J recombination.Molecular immunology · 2020Article
- Transposons to V(D)J Recombination: Evolution of the RAG Reaction.Trends in immunology · 2019Article
- Alternative DNA secondary structure formation affects RNA polymerase II promoter-proximal pausing in human.Genome biology · 2018Article
- On being the right size: antibody repertoire formation in the mouse and human.Immunogenetics · 2018Review
- Structural and Mechanistic Implications of Rearrangement Frequencies within Human TCRBV Genes.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- HCoDES reveals chromosomal DNA end structures with single-nucleotide resolution.Molecular cell · 2014Article
- Illegitimate V(D)J recombination-mediated deletions in Notch1 and Bcl11b are not sufficient for extensive clonal expansion and show minimal age or sex bias in frequency or junctional processing.Mutation research · 2014Article
- The shape of the lymphocyte receptor repertoire: lessons from the B cell receptor.Frontiers in immunology · 2013Review
- Resolution of complex ends by Nonhomologous end joining - better to be lucky than good?Genome integrity · 2012Article
- Cernunnos influences human immunoglobulin class switch recombination and may be associated with B cell lymphomagenesis.The Journal of experimental medicine · 2012Article
- Article
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3 authors.
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Abstract
V(D)J recombination events are initiated by cleavage at gene segments by the RAG1:RAG2 complex, which results in hairpin formation at the coding ends. The hairpins are opened by the Artemis:DNA-PKcs complex, and then joined via the nonhomologous DNA end joining (NHEJ) process. Here we examine the opening of the hairpinned coding ends from all of the 39 functional human V(H) elements. We find that there is some sequence-dependent variation in the efficiency and even the position of hairpin opening by Artemis:DNA-PKcs. The hairpin opening efficiency varies over a 7-fold range. The hairpin opening position varies over the region from 1 to 4 nt 3' of the hairpin tip, leading to a 2-8 nt single-stranded 3' overhang at each coding end. This information provides greater clarity on the extent to which the hairpin opening position contributes to junctional diversification in V(D)J recombination.
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